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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells.

http://hdl.handle.net/10191/42092
http://hdl.handle.net/10191/42092
428b46a2-06ea-4f2f-8278-37ec1373e958
名前 / ファイル ライセンス アクション
h27ndk337.pdf 本文 (1.7 MB)
h27ndk337_a.pdf 要旨 (522.5 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-09-11
タイトル
タイトル Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells.
タイトル
言語 en
タイトル Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells.
言語
言語 eng
キーワード
主題Scheme Other
主題 Innate immunity
キーワード
主題Scheme Other
主題 Streptococcus pyogenes
キーワード
主題Scheme Other
主題 Virulence factor
キーワード
主題Scheme Other
主題 CAMP factor
キーワード
主題Scheme Other
主題 Phagocytosis
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル Streptococcus pyogenesの産生するCAMP factorはRAW264.7細胞の貪食能を低下させる
著者 Kurosawa, Mie

× Kurosawa, Mie

WEKO 50824

Kurosawa, Mie

Search repository
著者別名
識別子 50825
識別子Scheme WEKO
姓名 黒澤, 美絵
抄録
内容記述タイプ Abstract
内容記述 Streptococcus pyogenes produces molecules that inhibit the function of human immune system, thus allowing the pathogen to grow and spread in tissues. It is known that S. pyogenes CAMP factor increases erythrocytosis induced by Staphylococcus aureus b-hemolysin. However, the effects of CAMP factor for immune cells are unclear. In this study, we investigated the effects of CAMP factor to macrophages. Western blotting analysis demonstrated that all examined strains expressed CAMP factor protein. In the presence of calcium or magnesium ion, CAMP factor was significantly released in the supernatant. In addition, both culture supernatant from S. pyogenes strain SSI-9 and recombinant CAMP factor dose-dependently induced vacuolation in RAW 264.7 cells, but the culture supernatant from Dcfa isogenic mutant strain did not. CAMP factor formed oligomers in RAW 264.7 cells in a time-dependent manner. CAMP factor suppressed cell proliferation via G2 phase cell cycle arrest without inducing cell death. Furthermore, CAMP factor reduced the uptake of S. pyogenes and phagocytic activity indicator by RAW 264.7 cells. These results suggest that CAMP factor works as a macrophage dysfunction factor. Therefore, we conclude that CAMP factor allows S. pyogenes to escape the host immune system, and contribute to the spread of streptococcal infection.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4139号. 学位記番号: 新大院博(歯)甲第337号. 学位授与年月日: 平成28年3月23日
内容記述
内容記述タイプ Other
内容記述 Microbes and Infection. 2016, 18(2), 118-127.
書誌情報 発行日 2016-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.micinf.2015.10.003
権利
権利情報 Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2016-03-23
学位授与番号
学位授与番号 13101甲第4139号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第337号
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