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The Kidney Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling
http://hdl.handle.net/10191/35561
http://hdl.handle.net/10191/35561093ad3dd-a2d2-4954-a9b8-39306d9fd341
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本文 (3.1 MB)
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要旨 (210.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-12-14 | |||||
| タイトル | ||||||
| タイトル | The Kidney Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling | |||||
| タイトル | ||||||
| タイトル | The Kidney Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | トランスクリプトームと抗体プロテオーム解析による腎臓トランスクリプトミクスとプロテオミクス | |||||
| 著者 |
Habuka, Masato
× Habuka, Masato |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50662 | |||||
| 姓名 | 羽深, 将人 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To understand renal functions and disease, it is important to define the molecular constituents of the various compartments of the kidney. Here, we used comparative transcriptomic analysis of all major organs and tissues in the human body, in combination with kidney tissue micro array based immunohistochemistry, to generate a comprehensive description of the kidney-specific transcriptome and proteome. A special emphasis was placed on the identification of genes and proteins that were elevated in specific kidney subcompartments. Our analysis identified close to 400 genes that had elevated expression in the kidney, as compared to the other analysed tissues, and these were further subdivided, depending on expression levels, into tissue enriched, group enriched or tissue enhanced. Immunohistochemistry allowed us to identify proteins with distinct localisation to the glomeruli (n=11), proximal tubules (n=120), distal tubules (n=9) or collecting ducts (n=8). Among the identified kidney elevated transcripts, we found several proteins not previously characterised or identified as elevated in kidney. This description of the kidney specific transcriptome and proteome provides a resource for basic and clinical research to facilitate studies to understand kidney biology and disease. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4069号. 学位記番号: 新大院博（医）甲第658号. 学位授与年月日: 平成27年9月24日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PLoS ONE. 2014, 9(12), e116125. | |||||
| 書誌情報 | 発行日 2015-09-24 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1371/journal.pone.0116125 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-09-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4069号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第658号 | |||||
