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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy

http://hdl.handle.net/10191/35556
d5134c5a-1224-4c4f-95d5-9efe147813e5
名前 / ファイル ライセンス アクション
h27nmk653.pdf 本文 (2.3 MB)
h27nmk653_a.pdf 要旨 (163.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2015-12-14
タイトル
タイトル Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy
タイトル
言語 en
タイトル Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 抗癌剤を用いたリンパ球除去後の抗腫瘍免疫における、抗癌剤耐性エフェクターおよび制御性T cellsの重要な役割
著者 Saida, Yu

× Saida, Yu

WEKO 50651

Saida, Yu

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著者別名
識別子
識別子 50652
識別子Scheme WEKO
姓名
姓名 才田, 優
抄録
内容記述タイプ Abstract
内容記述 Antitumor immunity is augmented by cytotoxic lymphodepletion therapies. Adoptively transferred naive and effector T cells proliferate extensively and show enhanced antitumor effects in lymphopenic recipients. Although the impact of lymphodepletion on transferred donor T cells has been well evaluated, its influence on recipient T cells is largely unknown. The current study demonstrates that both regulatory T cells (Tregs) and effector CD8^+ T cells from lymphopenic recipients play critical roles in the development of antitumor immunity after lymphodepletion. Cyclophosphamide (CPA) treatment depleted lymphocytes more efficiently than other cytotoxic agents; however, the percentage of CD4^+CD25^+ Forkhead box P3^+ Tregs was significantly increased in CPA-treated lymphopenic mice. Depletion of these chemoresistant Tregs following CPA treatment and transfer of naive CD4^+ T cells augmented the antitumor immunity and significantly suppressed tumor progression. Further analyses revealed that recipient CD8^+ T cells were responsible for this augmentation. Using Rag2^<-/-> mice or depletion of recipient CD8^+ T cells after CPA treatment abrogated the augmentation of antitumor effects in CPA-treated reconstituted mice. The transfer of donor CD4^+ T cells enhanced the proliferation of CD8^+ T cells and the priming of tumor-specific CD8^+ T cells originating from the lymphopenic recipients. These results highlight the importance of the recipient cells surviving cytotoxic regimens in cancer immunotherapies.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4064号. 学位記番号: 新大院博(医)甲第653号. 学位授与年月日: 平成27年9月24日
内容記述
内容記述タイプ Other
内容記述 The Journal of Immunology. 2015, 195(2), 726-735.
書誌情報 発行日 2015-09-24
出版者
出版者 新潟大学
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.4049/jimmunol.1401468
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2015-09-24
学位授与番号
学位授与番号 13101甲第4064号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第653号
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