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Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy
http://hdl.handle.net/10191/35556
d5134c5a-1224-4c4f-95d5-9efe147813e5
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2015-12-14 | |||||
タイトル | ||||||
タイトル | Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 抗癌剤を用いたリンパ球除去後の抗腫瘍免疫における、抗癌剤耐性エフェクターおよび制御性T cellsの重要な役割 | |||||
著者 |
Saida, Yu
× Saida, Yu |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 50652 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | 才田, 優 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Antitumor immunity is augmented by cytotoxic lymphodepletion therapies. Adoptively transferred naive and effector T cells proliferate extensively and show enhanced antitumor effects in lymphopenic recipients. Although the impact of lymphodepletion on transferred donor T cells has been well evaluated, its influence on recipient T cells is largely unknown. The current study demonstrates that both regulatory T cells (Tregs) and effector CD8^+ T cells from lymphopenic recipients play critical roles in the development of antitumor immunity after lymphodepletion. Cyclophosphamide (CPA) treatment depleted lymphocytes more efficiently than other cytotoxic agents; however, the percentage of CD4^+CD25^+ Forkhead box P3^+ Tregs was significantly increased in CPA-treated lymphopenic mice. Depletion of these chemoresistant Tregs following CPA treatment and transfer of naive CD4^+ T cells augmented the antitumor immunity and significantly suppressed tumor progression. Further analyses revealed that recipient CD8^+ T cells were responsible for this augmentation. Using Rag2^<-/-> mice or depletion of recipient CD8^+ T cells after CPA treatment abrogated the augmentation of antitumor effects in CPA-treated reconstituted mice. The transfer of donor CD4^+ T cells enhanced the proliferation of CD8^+ T cells and the priming of tumor-specific CD8^+ T cells originating from the lymphopenic recipients. These results highlight the importance of the recipient cells surviving cytotoxic regimens in cancer immunotherapies. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 甲第4064号. 学位記番号: 新大院博(医)甲第653号. 学位授与年月日: 平成27年9月24日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of Immunology. 2015, 195(2), 726-735. | |||||
書誌情報 | 発行日 2015-09-24 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.4049/jimmunol.1401468 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2015-09-24 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4064号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第653号 |