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The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer
http://hdl.handle.net/10191/35551
http://hdl.handle.net/10191/35551cba1cafd-171f-4845-a8b3-cf4dc6a58e88
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本文 (485.5 kB)
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要旨 (224.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-12-14 | |||||
| タイトル | ||||||
| タイトル | The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer | |||||
| タイトル | ||||||
| タイトル | The effectiveness of endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Superficial esophageal cancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Endoscopic submucosal dissection | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chemoradiotherapy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Combination | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pericardial effusion | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 表在型食道癌に対する内視鏡的粘膜下層剝離術後の化学放射線療法の有用性 | |||||
| 著者 |
Kawaguchi, Gen
× Kawaguchi, Gen |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50642 | |||||
| 姓名 | 川口, 弦 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: To evaluate the risks and benefits of endoscopic submucosal dissection (ESD) in addition to chemoradiotherapy (CRT) for the treatment of superficial esophageal squamous cell carcinoma (SESCC). Methods and materials: We retrospectively reviewed the treatment outcomes of 47 patients with SESCC treated between October 2000 and December 2011. Sixteen patients with invasion into the submucosal layer (T1b) or the muscularis mucosa (m3) with positive vascular invasion were treated with CRT after ESD\n(ESD-CRT group). The lymph node area was irradiated to a total dose of 40–44 Gy and a boost radiation was administered if PET-positive lymph nodes or positive margins were observed. The remaining 31 patients received definitive CRT only (dCRT group). Results: The radiation field was significantly larger in the ESD-CRT group; the "long T" was used in 11 patients (35.4%) in the dCRT group and 15 (93.7%) in the ESD-CRT group (p = 0.0001). The total radiation dose was smaller in the ESD-CRT group; 40 Gy was used in 10 patients (62.5%) in the ESD-CRT group and all but one patient in the dCRT group received ≥60 Gy (p = 0.00001). The 3-year overall survival rates in the dCRT and ESD-CRT groups were 63.2% and 90.0% respectively (p = 0.118). Recurrence developed in nine patients (29.0%) in the dCRT group and one (6.3%) in the ESD-CRT group. Local recurrence was observed in six patients (19%) in the dCRT group and none in the ESD-CRT-group (p = 0.029). Pericardial effusion (≥Grade 3) occurred in three patients (9.7%) in the dCRT group and none in the ESD-CRT group. Conclusions: ESD followed by CRT is an effective and safe approach for SESCC at m3 or T1b. This combination of ESD and CRT improves the local control rate, and it could decrease the number of cardiac toxicities due to a radiation-dose reduction relative to CRT alone. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4059号. 学位記番号: 新大院博（医）甲第648号. 学位授与年月日: 平成27年9月24日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Radiation Oncology. 2015, 10, 31. | |||||
| 書誌情報 | p. 1-7, 発行日 2015-09-24 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1186/s13014-015-0337-4 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C) 2015 Kawaguchi et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-09-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4059号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第648号 | |||||
