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Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour
http://hdl.handle.net/10191/32287
http://hdl.handle.net/10191/32287d8ba0bb1-56a0-4cbc-83ed-22d0a3f03285
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本文 (2.4 MB)
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要旨 (161.1 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-06-03 | |||||
| タイトル | ||||||
| タイトル | Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour | |||||
| タイトル | ||||||
| タイトル | Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a pre-neoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Barrett’s oesophagus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cardiac-type epithelium | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CDX2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intestinal metaplasia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tumour immunophenotype | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | バレット食道における腸上皮化生は前腫瘍状態というより副現象かもしれない，そしてCDX2陽性噴門腺型上皮が微小なバレット腫瘍と関連する | |||||
| 著者 |
Watanabe, Gen
× Watanabe, Gen |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50628 | |||||
| 姓名 | 渡邉, 玄 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aims: Although intestinal-type epithelium in Barrett’s oesophagus has been traditionally recognised as having a distinct malignant potential, whether this also holds true for cardiac-type epithelium remains controversial. The aim of this study was to identify highly associated type of epithelium with Barrett’s tumour. Methods and results: We analysed tumours and the corresponding background mucosa with special regard to tumour size in 40 cases of superficial Barrett’s tumour by using mmunohistochemical staining for CDX2, CD10, MUC2, MUC5AC, and MUC6. Intestinal metaplasia in tumour-adjacent mucosa was not associated with tumour size, but was significantly correlated with the extent of Barrett’s oesophagus (P < 0.001). Majority (69.2%, 9/13) of small tumours (≤10 mm in size) had no intestinal metaplasia in adjacent non-neoplastic mucosae. Minute (≤5 mm) tumours were significantly associated with gastric immunophenotype (P < 0.001). Purely gastric-immunophenotype tumour cells expressed CDX2, and cardiac-type epithelium adjacent to small tumours also displayed low-level CDX2 expression. Conclusions: Our data suggest that intestinal metaplasia in Barrett’s oesophagus is an epiphenomenon rather than a pre-neoplastic condition and that CDX2-positive cardiac-type epithelium is highly associated with minute Barrett’s tumour. Further prospective studies are needed to evaluate the risk of malignancy of cardiac-type epithelium with regard to sub-morphological intestinalisation. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 乙第2188号. 学位記番号: 新大博（医）乙第1777号. 学位授与年月日: 平成27年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Histopathology. 2015, 66(2), 201-214. | |||||
| 書誌情報 | p. 1-14, 発行日 2015-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1111/his.12486 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (C) 2014 Watanabe G. et al. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101乙第2188号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大博（医）乙第1777号 | |||||
