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A negative correlation was observed between periodontitis and truncal bone mineral density (BMD) in postmenopausal women. The C allele carriers of a genetic polymorphism IL-6-572G/C have higher levels of serum IL-6 compared to G allele carriers. We investigated the possible effect of IL-6-572G/C polymorphism on the relationship between low BMD and periodontitis in postmenopausal women. Subjects and methods: A total of 300 postmenopausal Japanese women who lived in Yokogoshi area of Niigata City, Japan, participated in this study. Genomic DNA was extracted from peripheral blood. The IL-6-572G/C genotypes were determined by the restriction fragment length polymorphism method. Bone mineral density (BMD) of right femoral neck and serum bone metabolism markers were measured. Low BMD was defined to have the BMD \u003c 80% of the mean for young adults. Periodontal parameters at two sites per tooth were measured. 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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women

http://hdl.handle.net/10191/32178
http://hdl.handle.net/10191/32178
231e492c-0522-4f1e-9582-6fd04a3fa9ed
名前 / ファイル ライセンス アクション
h26ndk322.pdf 本文 (408.9 kB)
h26ndk322_a.pdf 要旨 (203.9 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2015-05-28
タイトル
タイトル Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women
タイトル
言語 en
タイトル Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women
言語
言語 eng
キーワード
主題Scheme Other
主題 IL-6
キーワード
主題Scheme Other
主題 Polymorphism
キーワード
主題Scheme Other
主題 Low BMD
キーワード
主題Scheme Other
主題 Periodontitis
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル IL-6 遺伝子多型が歯周炎と Low BMD に与える影響
著者 Hanai, Yuki

× Hanai, Yuki

WEKO 50570

Hanai, Yuki

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著者別名
識別子 50571
識別子Scheme WEKO
姓名 花井, 悠貴
抄録
内容記述タイプ Abstract
内容記述 Objective: IL-6 plays critical roles in bone resorption and the pathogenesis of periodontitis in both inflammation and alveolar bone loss. A negative correlation was observed between periodontitis and truncal bone mineral density (BMD) in postmenopausal women. The C allele carriers of a genetic polymorphism IL-6-572G/C have higher levels of serum IL-6 compared to G allele carriers. We investigated the possible effect of IL-6-572G/C polymorphism on the relationship between low BMD and periodontitis in postmenopausal women. Subjects and methods: A total of 300 postmenopausal Japanese women who lived in Yokogoshi area of Niigata City, Japan, participated in this study. Genomic DNA was extracted from peripheral blood. The IL-6-572G/C genotypes were determined by the restriction fragment length polymorphism method. Bone mineral density (BMD) of right femoral neck and serum bone metabolism markers were measured. Low BMD was defined to have the BMD < 80% of the mean for young adults. Periodontal parameters at two sites per tooth were measured. Results: Serum osteocalcin levels were significantly lower in the IL-6-572G/G genotype (p = 0.025). In the -572G allele non-carriers, percentages of PPD > 4 mm sites were significantly higher in low BMD group compared with the healthy control group (p = 0.021). Logistic regression analysis revealed low BMD to be associated with periodontitis (Odds ratio = 1.736, p = 0.027) after adjusted with IL-6-572G carriage, age, serum albumin level. Conclusions: IL-6-572G/C polymorphism was not an independent risk factor of low BMD or periodontitis, but may affect the relationship between the two diseases in postmenopausal Japanese women.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4009号. 学位記番号: 新大院博(歯)甲第322号. 学位授与年月日: 平成27年3月23日
内容記述
内容記述タイプ Other
内容記述 Archives of Oral Biology. 2015, 60(4), 533-539.
書誌情報 発行日 2015-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.archoralbio.2014.12.005
権利
権利情報 Copyright(C) 2015 Elsevier
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2015-03-23
学位授与番号
学位授与番号 13101甲第4009号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第322号
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