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Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women
http://hdl.handle.net/10191/32178
http://hdl.handle.net/10191/32178231e492c-0522-4f1e-9582-6fd04a3fa9ed
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本文 (408.9 kB)
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要旨 (203.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2015-05-28 | |||||
| タイトル | ||||||
| タイトル | Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women | |||||
| タイトル | ||||||
| タイトル | Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IL-6 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Polymorphism | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Low BMD | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Periodontitis | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | IL-6 遺伝子多型が歯周炎と Low BMD に与える影響 | |||||
| 著者 |
Hanai, Yuki
× Hanai, Yuki |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50571 | |||||
| 姓名 | 花井, 悠貴 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: IL-6 plays critical roles in bone resorption and the pathogenesis of periodontitis in both inflammation and alveolar bone loss. A negative correlation was observed between periodontitis and truncal bone mineral density (BMD) in postmenopausal women. The C allele carriers of a genetic polymorphism IL-6-572G/C have higher levels of serum IL-6 compared to G allele carriers. We investigated the possible effect of IL-6-572G/C polymorphism on the relationship between low BMD and periodontitis in postmenopausal women. Subjects and methods: A total of 300 postmenopausal Japanese women who lived in Yokogoshi area of Niigata City, Japan, participated in this study. Genomic DNA was extracted from peripheral blood. The IL-6-572G/C genotypes were determined by the restriction fragment length polymorphism method. Bone mineral density (BMD) of right femoral neck and serum bone metabolism markers were measured. Low BMD was defined to have the BMD < 80% of the mean for young adults. Periodontal parameters at two sites per tooth were measured. Results: Serum osteocalcin levels were significantly lower in the IL-6-572G/G genotype (p = 0.025). In the -572G allele non-carriers, percentages of PPD > 4 mm sites were significantly higher in low BMD group compared with the healthy control group (p = 0.021). Logistic regression analysis revealed low BMD to be associated with periodontitis (Odds ratio = 1.736, p = 0.027) after adjusted with IL-6-572G carriage, age, serum albumin level. Conclusions: IL-6-572G/C polymorphism was not an independent risk factor of low BMD or periodontitis, but may affect the relationship between the two diseases in postmenopausal Japanese women. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（歯学）. 報告番号: 甲第4009号. 学位記番号: 新大院博（歯）甲第322号. 学位授与年月日: 平成27年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Archives of Oral Biology. 2015, 60(4), 533-539. | |||||
| 書誌情報 | 発行日 2015-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.archoralbio.2014.12.005 | |||||
| 権利 | ||||||
| 権利情報 | Copyright(C) 2015 Elsevier | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2015-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4009号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（歯）甲第322号 | |||||
