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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

http://hdl.handle.net/10191/32176
http://hdl.handle.net/10191/32176
22a16981-2a07-4f37-8622-9a898f669a8d
名前 / ファイル ライセンス アクション
h26ndk320.pdf 本文 (1.0 MB)
h26ndk320_a.pdf 要旨 (212.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2015-10-14
タイトル
タイトル Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
タイトル
言語 en
タイトル Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 口腔内病原性細菌が腸内細菌叢の変動に関連した全身性の炎症と代謝性の変化を誘導する
著者 Arimatsu, Kei

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WEKO 50566

Arimatsu, Kei

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著者別名
識別子 50567
識別子Scheme WEKO
姓名 有松, 圭
抄録
内容記述タイプ Abstract
内容記述 Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty liver disease. Although bacteremias from dental plaque and/or elevated circulating inflammatory cytokines emanating from the inflamed gingiva are suspected mechanisms linking periodontitis and these diseases, direct evidence is lacking. We hypothesize that disturbances of the gut microbiota by swallowed bacteria induce a metabolic endotoxemia leading metabolic disorders. To investigate this hypothesis, changes in the gut microbiota, insulin and glucose intolerance, and levels of tissue inflammation were analysed in mice after oral administration of Porphyromonas gingivalis, a representative periodontopathogens. Pyrosequencing revealed that the population belonging to Bacteroidales was significantly elevated in P. gingivalis-administered mice which coincided with increases in insulin resistance and systemic inflammation. In P. gingivalis-administered mice blood endotoxin levels tended to be higher, whereas gene expression of tight junction proteins in the ileum was significantly decreased. These results provide a new paradigm for the interrelationship between periodontitis and systemic diseases.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第4007号. 学位記番号: 新大院博(歯)甲第320号. 学位授与年月日: 平成27年3月23日
内容記述
内容記述タイプ Other
内容記述 Scientific Reports. 2014, 4, 4828.
書誌情報 発行日 2015-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/srep04828
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2015-03-23
学位授与番号
学位授与番号 13101甲第4007号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第320号
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