{"_buckets": {"deposit": "387b1f8e-139a-41c7-b534-bbd45fcfcc30"}, "_deposit": {"id": "5542", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "5542"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00005542"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "An anti-angiogenic factor VEGF_\u003c165\u003eb expression and inhibitory effect on angiogenesis after focal cerebral ischemia in rats"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2015-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u3010\u80cc\u666f\u3011\u8133\u6897\u585e\u5f8c\u306e\u56de\u5fa9\u671f\u306b\u304a\u3044\u3066\uff0c \u6a5f\u80fd\u56de\u5fa9\u3092\u4fc3\u9032\u3055\u305b\u308b\u6cbb\u7642\u6cd5\u306e\u78ba\u7acb\u304c\u671b\u307e\u308c\u3066\u3044\u308b\u304c\uff0c \u672a\u3060\u81e8\u5e8a\u5fdc\u7528\u306f\u306a\u3055\u308c\u3066\u3044\u306a\u3044\uff0e \u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50 \uff08vascular endothelial growth factor; VEGF\uff09\u306f\uff0c\u8840\u7ba1\u65b0\u751f\u3092\u5f37\u529b\u306b\u4fc3\u9032\u3059\u308b\u8840\u7ba1\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u56e0\u5b50\u3067\u3042\u308a\uff0c \u8133\u6897\u585e\u8d85\u6025\u6027\u671f\u306b\u304a\u3044\u3066\u8840\u6db2\u8133\u95a2\u9580\u3092\u7834\u7dbb\u3055\u305b\uff0c \u3055\u3089\u306b\u8840\u6813\u6eb6\u89e3\u7642\u6cd5\u5f8c\u306e\u8133\u51fa\u8840\u5408\u4f75\u75c7\u306b\u95a2\u4e0e\u3059\u308b\uff0e\u4e00\u65b9\uff0cVEGF \u306e\u30b9\u30d7\u30e9\u30a4\u30b7\u30f3\u30b0\u30d0\u30ea\u30a2\u30f3\u30c8\u3067\u3042\u308bVEGF_\u003c165\u003eb \u306f\uff0cVEGF \u3068VEGF \u53d7\u5bb9\u4f53\u306e\u7d50\u5408\u3092\u7af6\u5408\u7684\u306b\u963b\u5bb3\u3057\uff0c\u5185\u56e0\u6027\u306eVEGF\u963b\u5bb3\u56e0\u5b50\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\uff0e \u3057\u304b\u3057\uff0c \u8133\u865a\u8840\u5f8c\u306eVEGF_\u003c165\u003eb \u306e\u767a\u73fe\u3084\u5c40\u5728\u306e\u5909\u5316\uff0c \u8840\u7ba1\u65b0\u751f\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u3067\u3042\u308b\uff0e\u3010\u76ee\u7684\u3011VEGF_\u003c165\u003eb \u304c\u8133\u865a\u8840\u5f8c\u306e\u8840\u7ba1\u65b0\u751f\u3092\u963b\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\uff0e \u3053\u306e\u305f\u3081\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u5f8c\u306eVEGF_\u003c165\u003eb \u306e\u767a\u73fe\u304a\u3088\u3073\u5c40\u5728\u306e\u5909\u5316\u3068\uff0cVEGF_\u003c165\u003eb \u304c\u8840\u7ba1\u65b0\u751f\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u3053\u3068\uff0e\u3010\u65b9\u6cd5\u3011\u96c4Sprague- Dawley \u30e9\u30c3\u30c8\u3092\u7528\u3044\u305f\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u3092\u7528\u3044\uff0c \u865a\u8840\u5f8c1 \u65e5\uff0c 3 \u65e5\uff0c 7 \u65e5\uff0c 14 \u65e5\uff0c \u304a\u3088\u3073\u5bfe\u7167 \uff08\u975e\u865a\u8840\u7fa4\uff09 \u306e\u5927\u8133\u76ae\u8cea\u3092\u8133\u8a66\u6599\u3068\u3057\u3066\u63a1\u53d6\u3057\u305f\uff0eVEGF_\u003c165\u003eb \u306e\u7d4c\u6642\u7684\u5909\u5316\u3068\u5c40\u5728\u3092\uff0c\u6297VEGF_\u003c165\u003eb \u6297\u4f53\u3092\u7528\u3044\u305f\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u3068\u514d\u75ab\u7d44\u7e54\u5316\u5b66\uff0c \u86cd\u51492\u91cd\u67d3\u8272\u306b\u3088\u308a\u8a55\u4fa1\u3057\u305f\uff0e \u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5897\u6b96\u3092\u691c\u51fa\u3059\u308b\u305f\u3081Ki-67 \uff08\u7d30\u80de\u5897\u6b96\u30de\u30fc\u30ab\u30fc\uff09\uff0c\u304a\u3088\u3073endothelial barrier antigen \uff08EBA\uff1b \u8840\u7ba1\u5185\u76ae\u30de\u30fc\u30ab\u30fc\uff09 \u306e\u86cd\u5149\u4e8c\u91cd\u67d3\u8272\u3092\u884c\u3063\u305f\uff0e \u3055\u3089\u306bVEGF-VEGF\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u65b0\u751f\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bendocan\u306b\u5bfe\u3059\u308b\u6297\u4f53\u3092\u7528\u3044\u305f\u30a6\u30a7\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u3068\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u3092\u884c\u3044\uff0cVEGF_\u003c165\u003eb \u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u5897\u6b96\uff0cVEGF-VEGF\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u65b0\u751f\u306e\u95a2\u4fc2\u3092\u691c\u8a0e\u3057\u305f\uff0e\u3010\u7d50\u679c\u3011VEGF_\u003c165\u003eb \u306f\u865a\u8840\u5f8c3 \u65e5\u76ee\u3092\u30d4\u30fc\u30af\u3068\u3057\u3066\u5897\u52a0\u3057\uff0c\u865a\u8840\u4e2d\u5fc3\u90e8\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u767a\u73fe\u3057\u305f\uff0e \u4e00\u65b9\uff0cVEGF \u306f\u865a\u8840\u8fba\u7e01\u90e8\u306b\u767a\u73fe\u3057\uff0c \u4e21\u8005\u306f\u5171\u5c40\u5728\u3057\u306a\u304b\u3063\u305f\uff0e Ki-67 \u3067\u8a55\u4fa1\u3057\u305f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5897\u6b96\u306f\uff0c \u865a\u8840\u5f8c3\u65e5\u76ee\u3092\u30d4\u30fc\u30af\u3068\u3057\u3066\u865a\u8840\u4e2d\u5fc3\u90e8\u306b\u304a\u3044\u3066\u5897\u52a0\u3057\u305f\uff0e \u3057\u304b\u3057endocan\u306f\u865a\u8840\u5f8c7\u65e5\u76ee\u4ee5\u964d\u306b\u5897\u52a0\u3059\u308b\u3082\u306e\u306e\uff0c \u865a\u8840\u4e2d\u5fc3\u90e8\u306b\u306f\u8a8d\u3081\u305a\uff0c \u865a\u8840\u5468\u8fba\u90e8\u306e\u8840\u7ba1\u306e\u307f\u306b\u767a\u73fe\u3057\u3066\u3044\u305f\uff0e\u3010\u8003\u5bdf\u3011\u865a\u8840\u4e2d\u5fc3\u90e8\u306e\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306f\u5897\u6b96\u3059\u308b\u3082\u306e\u306e\uff0cVEGF_\u003c165\u003eb \u306e\u767a\u73fe\u306b\u3088\u308a\uff0cVEGF-VEGF \u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u4ecb\u3057\u305f\u8840\u7ba1\u65b0\u751f\u304c\u963b\u5bb3\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u305f\uff0e\u3010\u7d50\u8ad6\u3011VEGF_\u003c165\u003eb \u306f\u8133\u6897\u585e\u306e\u56de\u5fa9\u671f\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u3092\u4fc3\u9032\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6a19\u7684\u5206\u5b50\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b\uff0e", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c3971\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c617\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621027\u5e743\u670823\u65e5", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c617\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c3971\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "50458", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ishikawa, Masanori"}]}]}, "item_6_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66"}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u77f3\u5ddd, \u6b63\u5178"}], "nameIdentifiers": [{"nameIdentifier": "50457", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h26nmk617.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/5542/files/h26nmk617.pdf"}, "version_id": "8ffdf8d5-7a4a-4d17-b34e-5450f106b8ae"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h26nmk617_a.pdf", "filesize": [{"value": "160.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 160500.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/5542/files/h26nmk617_a.pdf"}, "version_id": "19cb9dee-5d1f-42d4-a02c-bcff4456a06f"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840", "subitem_subject_scheme": "Other"}, {"subitem_subject": "VEGF_\u003c165\u003eb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u65b0\u751f", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u865a\u8840\u4e2d\u5fc3\u90e8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30e9\u30c3\u30c8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Transient focal cerebral ischemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Angiogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ischemic core", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rat", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "\u30e9\u30c3\u30c8\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50VEGF_\u003c165\u003eb\u306e\u767a\u73fe\u3068\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30e9\u30c3\u30c8\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50VEGF_\u003c165\u003eb\u306e\u767a\u73fe\u3068\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u306e\u691c\u8a0e"}, {"subitem_title": "\u30e9\u30c3\u30c8\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50VEGF_\u003c165\u003eb\u306e\u767a\u73fe\u3068\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/32255", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-06-03"}, "publish_date": "2015-06-03", "publish_status": "0", "recid": "5542", "relation": {}, "relation_version_is_last": true, "title": ["\u30e9\u30c3\u30c8\u4e00\u904e\u6027\u5c40\u6240\u8133\u865a\u8840\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50VEGF_\u003c165\u003eb\u306e\u767a\u73fe\u3068\u8840\u7ba1\u65b0\u751f\u6291\u5236\u4f5c\u7528\u306e\u691c\u8a0e"], "weko_shared_id": 2}