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Effect of Valproic acid on bone healing in rat
http://hdl.handle.net/10191/24558
http://hdl.handle.net/10191/245584fad3cfb-1f78-4b7b-abca-a731294f2c03
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要旨 (245.1 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2014-05-28 | |||||
タイトル | ||||||
タイトル | Effect of Valproic acid on bone healing in rat | |||||
タイトル | ||||||
タイトル | Effect of Valproic acid on bone healing in rat | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone regeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histone deacetylase inhibitors (HDACi) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | valproic acid (VPA) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone cavity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoblast | |||||
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資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | ラット骨欠損治癒におけるバルプロ酸の影響に関する研究 | |||||
著者 |
Rashid, Md.Mamunur
× Rashid, Md.Mamunur |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: Sufficient bone quality and quantity before placement of dental implant are necessary to achieve successful result. Although numerous materials and methods have been reported regarding bone augmentation, more reliable and feasible ones are still required in this field. Valproic acid (VPA) regulates osteoblast differentiation through Runx2-dependent transcriptional activation. The aim of the present study was to evaluate the effect of systemic administration of VPA on bone regeneration in rat maxillary bone cavity. Materials and Methods: Forty two Wistar rats were divided into control and experimental groups. Upper first and second molars were extracted at the age of 4 weeks. Three weeks after extraction, experimental group received intraperitoneal injection of VPA for 7 days prior to the preparation of bone cavity at the first molar area. Rats were sacrificed on day 3, 7, 14, and 21 and samples were prepared for micro-CT and histological analyses. Serum was used for alkaline phosphatase (ALP) activity measurement. Results: Micro-CT analysis showed higher amount of newly formed bone, bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and less trabecular separation (Tb. Sp) in experimental group than control group. VPA treated animals showed significantly higher ALP activities at 7, 14 and 21 days than control group. According to the histological observations, the amount of newly formed bone was clearly larger in experimental group at 7, 14, and 21 days than control group. rat maxillary bone cavity, it might be useful for the bone augmentation prior to, or upon implant therapy. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(歯学). 報告番号: 甲第3817号. 学位記番号: 新大院博(歯)甲第283号. 学位授与年月日: 平成25年9月20日 | |||||
書誌情報 | p. 1-28, 発行日 2013-09-20 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
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値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(歯学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2013-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101A3817 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(歯)甲第283号 |