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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Effect of Valproic acid on bone healing in rat

http://hdl.handle.net/10191/24558
http://hdl.handle.net/10191/24558
4fad3cfb-1f78-4b7b-abca-a731294f2c03
名前 / ファイル ライセンス アクション
h25ndk283.pdf 本文 (854.3 kB)
h25ndk283_a.pdf 要旨 (245.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2014-05-28
タイトル
タイトル Effect of Valproic acid on bone healing in rat
タイトル
言語 en
タイトル Effect of Valproic acid on bone healing in rat
言語
言語 eng
キーワード
主題Scheme Other
主題 bone regeneration
キーワード
主題Scheme Other
主題 histone deacetylase inhibitors (HDACi)
キーワード
主題Scheme Other
主題 valproic acid (VPA)
キーワード
主題Scheme Other
主題 bone cavity
キーワード
主題Scheme Other
主題 osteoblast
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル ラット骨欠損治癒におけるバルプロ酸の影響に関する研究
著者 Rashid, Md.Mamunur

× Rashid, Md.Mamunur

WEKO 50177

Rashid, Md.Mamunur

Search repository
抄録
内容記述タイプ Abstract
内容記述 Objectives: Sufficient bone quality and quantity before placement of dental implant are necessary to achieve successful result. Although numerous materials and methods have been reported regarding bone augmentation, more reliable and feasible ones are still required in this field. Valproic acid (VPA) regulates osteoblast differentiation through Runx2-dependent transcriptional activation. The aim of the present study was to evaluate the effect of systemic administration of VPA on bone regeneration in rat maxillary bone cavity. Materials and Methods: Forty two Wistar rats were divided into control and experimental groups. Upper first and second molars were extracted at the age of 4 weeks. Three weeks after extraction, experimental group received intraperitoneal injection of VPA for 7 days prior to the preparation of bone cavity at the first molar area. Rats were sacrificed on day 3, 7, 14, and 21 and samples were prepared for micro-CT and histological analyses. Serum was used for alkaline phosphatase (ALP) activity measurement. Results: Micro-CT analysis showed higher amount of newly formed bone, bone volume fraction (BV/TV), trabecular thickness (Tb.Th) and less trabecular separation (Tb. Sp) in experimental group than control group. VPA treated animals showed significantly higher ALP activities at 7, 14 and 21 days than control group. According to the histological observations, the amount of newly formed bone was clearly larger in experimental group at 7, 14, and 21 days than control group. rat maxillary bone cavity, it might be useful for the bone augmentation prior to, or upon implant therapy.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(歯学). 報告番号: 甲第3817号. 学位記番号: 新大院博(歯)甲第283号. 学位授与年月日: 平成25年9月20日
書誌情報 p. 1-28, 発行日 2013-09-20
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2013-09-20
学位授与番号
学位授与番号 13101A3817
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第283号
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