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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Auditory cortical areas activated by slow frequency-modulated sounds in mice

http://hdl.handle.net/10191/24543
http://hdl.handle.net/10191/24543
a90a2112-ceb1-410f-a550-c14659bf7699
名前 / ファイル ライセンス アクション
h25nmk564.pdf 本文 (1.4 MB)
h25nmk564_a.pdf 要旨 (218.1 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2014-05-28
タイトル
タイトル Auditory cortical areas activated by slow frequency-modulated sounds in mice
タイトル
言語 en
タイトル Auditory cortical areas activated by slow frequency-modulated sounds in mice
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 遅い周波数変調音に特異的に応答するマウス聴覚野領域
著者 Honma, Yuusuke

× Honma, Yuusuke

WEKO 50165

Honma, Yuusuke

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著者別名
識別子 50166
識別子Scheme WEKO
姓名 本間, 悠介
抄録
内容記述タイプ Abstract
内容記述 Species-specific vocalizations in mice have frequency-modulated (FM) components slower than the lower limit of FM direction selectivity in the core region of the mouse auditory cortex. To identify cortical areas selective to slow frequency modulation, we investigated tonal responses in the mouse auditory cortex using transcranial flavoprotein fluorescence imaging. For differentiating responses to frequency modulation from those to stimuli at constant frequencies, we focused on transient fluorescence changes after direction reversal of temporally repeated and superimposed FM sweeps. We found that the ultrasonic field (UF) in the belt cortical region selectively responded to the direction reversal. The dorsoposterior field (DP) also responded weakly to the reversal. Regarding the responses in UF, no apparent tonotopic map was found, and the right UF responses were significantly larger in amplitude than the left UF responses. The half-max latency in responses to FM sweeps was shorter in UF compared with that in the primary auditory cortex (A1) or anterior auditory field (AAF). Tracer injection experiments in the functionally identified UF and DP confirmed that these two areas receive afferent inputs from the dorsal part of the medial geniculate nucleus (MG). Calcium imaging of UF neurons stained with fura-2 were performed using a two-photon microscope, and the presence of UF neurons that were selective to both direction and direction reversal of slow frequency modulation was demonstrated. These results strongly suggest a role for UF, and possibly DP, as cortical areas specialized for processing slow frequency modulation in mice.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第3812号. 学位記番号: 新大院博(医)甲第564号. 学位授与年月日: 平成25年9月20日
内容記述
内容記述タイプ Other
内容記述 PLoS ONE. 2013, 8(7), e68113
書誌情報 発行日 2013-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1371/journal.pone.0068113
権利
権利情報 © 2013 Honma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2013-09-20
学位授与番号
学位授与番号 13101A3812
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第564号
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