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Up-regulation of prolactin receptor in the proximal tubular cells was induced in cardiac dysfunction model mice
http://hdl.handle.net/10191/24552
http://hdl.handle.net/10191/2455274a5c572-6650-4e95-a8c6-ab577d785dbc
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本文 (782.3 kB)
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要旨 (222.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2014-05-28 | |||||
| タイトル | ||||||
| タイトル | Up-regulation of prolactin receptor in the proximal tubular cells was induced in cardiac dysfunction model mice | |||||
| タイトル | ||||||
| タイトル | Up-regulation of prolactin receptor in the proximal tubular cells was induced in cardiac dysfunction model mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sodium transport | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cardio-renal | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bromocriptine | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 心機能低下マウスにおける近位尿細管プロラクチン受容体の発現増加 | |||||
| 著者 |
Tsuchida, Yohei
× Tsuchida, Yohei |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 50164 | |||||
| 姓名 | 土田, 陽平 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: In order to clarify the interaction between cardiac dysfunction and sodium homeostasis in the kidney, we used a murine model of cardiac dysfunction and investigated the effect on sodium transporters in renal tubular cells. Methods: Cardiac function was deteriorated by abdominal aortic banding, and the gene expression of sodium transporters in the kidneys was evaluated by real-time RT-PCR and compared with that in the kidneys of control mice. Results: Gene expression of all three variants of the murine prolactin receptor was enhanced by aortic banding. Upregulated prolactin receptor was distributed in the proximal tubular cells of the pars recta in the deep inner cortex and the outer stripe of the outer medulla. Prolactin has been reported to be a natriuretic hormone that inhibits proximal tubular Na^+/K^+-ATPase activity, resulting in reduced sodium reabsorption and the acceleration of natriuresis. Inhibition of endogenous prolactin secretion by bromocriptine administration decreased the urine sodium excretion in both aortic banding and control mice. On the other hand, excess exogenous prolactin administration enhanced urine potassium excretion in aortic banding mice. Furthermore, a high-sodium diet accelerated urinary sodium excretion, which was also significantly decreased by inhibition of endogenous prolactin secretion in aortic banding mice. Conclusion: We reported that the prolactin receptor was upregulated by aortic banding treatment. Prolactin-prolactin receptor interaction in the proximal tubular cells of the pars recta should involve a different mechanism of kaliuresis other than inhibition of Na^+/K^+-ATPase. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第3811号. 学位記番号: 新大院博（医）甲第563号. 学位授与年月日: 平成25年9月20日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Clinical and Experimental Nephrology. 2014, 18(1), 65-74 | |||||
| 書誌情報 | 発行日 2013-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1007/s10157-013-0820-x | |||||
| 権利 | ||||||
| 権利情報 | © Japanese Society of Nephrology | |||||
| 権利 | ||||||
| 権利情報 | The original publication is available at www.springerlink.com | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2013-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101A3811 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第563号 | |||||
