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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction

http://hdl.handle.net/10191/24547
http://hdl.handle.net/10191/24547
93e85d92-72d4-41b0-81ee-3006f5eb265f
名前 / ファイル ライセンス アクション
h25nmk557.pdf 本文 (316.5 kB)
h25nmk557_a.pdf 要旨 (206.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2014-05-28
タイトル
タイトル Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction
タイトル
言語 en
タイトル Serum Intestinal Fatty Acid Binding Protein in Patients with Small Bowel Obstruction
言語
言語 eng
キーワード
主題Scheme Other
主題 Biomarker
キーワード
主題Scheme Other
主題 I-FABP
キーワード
主題Scheme Other
主題 Small Bowel Obstruction
キーワード
主題Scheme Other
主題 Strangulation
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 腸閉塞患者における血中ヒト腸型脂肪酸結合蛋白濃度推移に関する検討
著者 Sakamoto, Kaoru

× Sakamoto, Kaoru

WEKO 50153

Sakamoto, Kaoru

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著者別名
識別子 50154
識別子Scheme WEKO
姓名 坂本, 薫
抄録
内容記述タイプ Abstract
内容記述 Purpose: The aims of this pilot study were to reveal the biological characteristics of serum I-FABP and explore its clinical utility as a biomarker in patients with small bowel obstruction (SBO). Methods: Serum I-FABP levels were measured in 37 consecutive patients with SBO between 2007 and 2008. Serum I-FABP levels were compared between ischemia (n = 10) and non-ischemia (n = 27) groups. Serum I-FABP levels were longitudinally analyzed in 21 patients who showed high (>2.0 ng/ml) serum I-FABP levels. The relationship between serum I-FABP level and length of damaged bowel was also analyzed. Results: Median serum I-FABP levels were 9.2 ng/ml in the ischemia group and 1.9 ng/ml in the non-ischemia group (p < 0.0001). The elevated I-FABP levels rapidly decreased after therapeutic intervention and normalized on the third day in all patients. Linear regression analysis revealed a positive correlation between I-FABP levels and lengths of surgically excised bowels (y = 2.527x - 7.660, r = 0.604, p = 0.0018). By setting the cutoff level at 7.2 ng/ml, the diagnostic ability of serum I-FABP was 70.0% in terms of sensitivity, 92.6% in terms of specificity, and 86.5% in terms of accuracy. Conclusion: Serum I-FABP sensitively reflects bowel damage in SBO patients and seems to be a potential biomarker for detecting small-bowel ischemia.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第3805号. 学位記番号: 新大院博(医)甲第557号. 学位授与年月日: 平成25年9月20日
内容記述
内容記述タイプ Other
内容記述 Surgical Science. 2013, 4(6), 302-307
書誌情報 発行日 2013-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.4236/ss.2013.46059
権利
権利情報 Copyright © 2013 Kaoru Sakamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2013-09-20
学位授与番号
学位授与番号 13101A3805
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第557号
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