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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 230 大学院自然科学研究科
  2. 60 博士学位論文
  3. 10 博士学位論文

Thymic involution with age : regression of the adrenal reticularis by peripheral T cells

http://hdl.handle.net/10191/20780
http://hdl.handle.net/10191/20780
2f827c64-a949-4638-adbf-ebb9dbd67f88
名前 / ファイル ライセンス アクション
D_S_R_K349.pdf 本文 (3.4 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-01-22
タイトル
タイトル Thymic involution with age : regression of the adrenal reticularis by peripheral T cells
タイトル
言語 en
タイトル Thymic involution with age : regression of the adrenal reticularis by peripheral T cells
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 加齢に伴う胸腺退縮機序:末梢T細胞による副腎皮質網状帯の統御
著者 Kushida, Yoshihiro

× Kushida, Yoshihiro

WEKO 50067

Kushida, Yoshihiro

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著者別名
識別子 50068
識別子Scheme WEKO
姓名 串田, 良祐
抄録
内容記述タイプ Abstract
内容記述 T cell dependent immune functions gradually decline with age. The thymus that produces T cells involutes after puberty, resulting in declines of thymic functions with age. It is thought that changes in the production of immunoregulatory hormones, including glucocorticoid (GC) that induces thymocyte death, result in thymic involution with age. However, it is possible that these hormones are not enough for this process because the amount of GC in the sera at a normal physiological state rarely increases with age. Recently, mice with abnormalities in the generation of a normal T cell repertoire are reported to not show thymic involution after puberty. Furthermore, the profile of thymic involution is inversely correlated with an increase in peripheral T cells. These results may indicate that a lack of functional, mature T cells in the periphery does not cause age-related thymic involution, suggesting that, during ontogeny, the gradual generation of peripheral T cells that encounter various environmental antigens can be activated and cause the post-puberty involution of the thymus. Based on this idea, I studied involvement of peripheral T cells in thymic involution after puberty. I found that the prevention of T cell generation delayed the initiation of thymic involution. On the other hand, the activation of T cells by anti-CD3 antibodies increased the serum concentration of GC and thymic atrophy, which was completely prevented by adrenalectomy. In the adrenals of growing mice, the activity of the zona fasciculata, which produces GC, increased and plateaued by the weaning period; however, the zona reticularis (ZR), which produces dehydroepiandrosterone (DHEA) that has anti-GC actions, started to decline just before puberty. These changes reflect the amounts of blood-circulating hormones. Thymic involution was significantly retarded by DHEA administration. The involution of ZR with age was not observed in athymic nude mice. However, the repopulation of T cells resulted in its atrophy. Thymic atrophy after immune stimulation was preceded continuously by the infiltration of activated T cells into the ZR, by the expression of the major histocompatibility complex (MHC) class II on ZR cells, and by the loss of ZR cells by apoptosis. Thus, T cells are involved in thymic involution through an increase in GC activity due to ZR cell-killing.
内容記述
内容記述タイプ Other
内容記述 新潟大学大学院自然科学研究科
内容記述
内容記述タイプ Other
内容記述 平成24年3月23日
内容記述
内容記述タイプ Other
内容記述 新大院博(理)甲第349号
書誌情報 p. 1-53, 発行日 2012-03-23
出版者
出版者 新潟大学
著者版フラグ
値 author
学位名
学位名 博士(理学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2012-03-23
学位授与番号
学位授与番号 13101甲第3648号
学位記番号
内容記述タイプ Other
内容記述 新大院博(理)甲第349号
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