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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol

http://hdl.handle.net/10191/23776
http://hdl.handle.net/10191/23776
8708975e-b03e-4ccf-8d00-c624aa37b48f
名前 / ファイル ライセンス アクション
000000251566.pdf 本文 (760.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-10-10
タイトル
タイトル The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol
タイトル
言語 en
タイトル The Use of Isoproterenol in Electrophysiologic Drug Testing in Patients with Sustained Ventricular Tachycardia : The Mechanism and Clinical Significance of Isoproterenol
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 持続型心室頻拍の薬効判定におけるイソプロテレノールの有用性についての研究 : イソプロテレノールの作用機序と臨床的意義
著者 Sato, Msahito

× Sato, Msahito

WEKO 48394

Sato, Msahito

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著者別名
識別子 48395
識別子Scheme WEKO
姓名 佐藤, 政仁
抄録
内容記述タイプ Abstract
内容記述 Isoproterenol has been used in electro-physiologic studies to facilitate the induction of ventricular tachycardia (VT) as well as in drug testing. However, the mechanism of the induction of VT and the clinical significance of the VT induced with isoproterenol have yet to be deternlined. The present study assessed the effects of isoproterenol in the induction of VT during drug testing in 23 patients (34 drug testings), and analyzed the patients'characteristics and electrophysiologic parameters. The standard protocol for inducing VT was used. Sustained monomorphic VT was induced in 15 testings after the use of isoproterenol (ineffective drug testing). In the other 19 testings, sustained VT was not induced even after the use of isoproterenol (effective drug testing). Isoproterenol altered the electrophysiologic parameters in a similar manner in the two testings. However, nonsustained VT was more frequently induced before isoproterenol in the ine汀ective drug testings: 60% vs 16% (P<0.05). This indicates that isoproterenol converted nonsustained VT into sustained VT, implying that isoproterenol improved the conduction within the slow conduction zone, resulting in VT which did not termi-nate spontaneously. Facilitated conduction outside the reentry circuit, namely, the intervening tissue between the stimulation site and the reentry circuit, likely, played a minor role. The majority of patients treated with an effective drug showed no recurrence of VT during the follow-up period.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 乙第1307号. 学位記番号: 新大博(医)乙第1215号. 学位授与年月日: 平成4年4月23日
内容記述
内容記述タイプ Other
内容記述 Acta Medica et Biologica. 1992, 40(1), 35-41.
書誌情報 p. 1-24, 発行日 1992-04-23
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 1992-04-23
学位授与番号
学位授与番号 13101B1307
学位記番号
内容記述タイプ Other
内容記述 新大博(医)乙第1215号
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