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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

中枢神経系の脱髄機序に関する研究

http://hdl.handle.net/10191/23504
http://hdl.handle.net/10191/23504
6a39ebf6-16f4-4edb-912a-d01300b8d522
名前 / ファイル ライセンス アクション
000000241892.pdf 本文 (1.8 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-10-08
タイトル
タイトル 中枢神経系の脱髄機序に関する研究
タイトル
言語 en
タイトル 中枢神経系の脱髄機序に関する研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 calpain (calcium-activated neutral protease)
キーワード
主題Scheme Other
主題 human brain myielin
キーワード
主題Scheme Other
主題 myelin-associated glyco@rotein
キーワード
主題Scheme Other
主題 triethyl tin
キーワード
主題Scheme Other
主題 acetazolamide
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル Study on the Mechanism of Demyelination in Central Nervous System
著者 柳澤, 勝彦

× 柳澤, 勝彦

WEKO 48370

柳澤, 勝彦

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著者別名
識別子 48371
識別子Scheme WEKO
姓名 Yanagisawa, Katsuhiko
抄録
内容記述タイプ Abstract
内容記述 Calcium-dependent protease was extracted from human brain myelin membrane and partially purified on a phenyl Sepharose CL, 4B column. It was activated by calcium ion in the millimolar range, and therefore was determined to be calpain II. This enzyme fraction was electrophoresed and immunostained with anti-chicken muscle calpain antibody, resulting in staining as a single band with apparent molecular weight of 80K. This protease degraded exogenous myelin-associated glycoprotein. From the present result, it is suggested that calpain is bound to myelin membranes and involved in the turnover of myelin proteins. The vacuolar degeneration was produced by oral administration of triethyl tin (TET). The wet weight of brain stems which seems to reflect the degree of accumulation of water increased during the administration of the toxin, whereas the activity of 2', 3'-cyclic nucleotide 3'-phosphodiesterase altered less remarkably. When TET was withdrawed from the drinking water, the rats showed a dramatic clinical improvement along with reduction in wet weight of brain stems. Treatment with acetazolamide following TET inhibited the clinical improvement and reduction in wet weight of brain stems. The present results indicates that central myelin has plasticity in recovering from the vacuolar degeneration by removing the accumulated fluid and carbonic anhydrase is possibly involved in the dehydration of myelin in such a recovery phase.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 乙第1141号. 学位記番号: 新大医博乙第1060号. 学位授与年月日: 平成3年4月16日
内容記述
内容記述タイプ Other
内容記述 新潟医学会雑誌. 1991, 105(5), 326-333.
書誌情報 p. 1-15, 発行日 1991-04-16
出版者
出版者 新潟大学
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 1991-04-16
学位授与番号
学位授与番号 13101B1141
学位記番号
内容記述タイプ Other
内容記述 新大医博乙第1060号
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