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中枢神経系の脱髄機序に関する研究
http://hdl.handle.net/10191/23504
http://hdl.handle.net/10191/235046a39ebf6-16f4-4edb-912a-d01300b8d522
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2013-10-08 | |||||
タイトル | ||||||
タイトル | 中枢神経系の脱髄機序に関する研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 中枢神経系の脱髄機序に関する研究 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | calpain (calcium-activated neutral protease) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human brain myielin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myelin-associated glyco@rotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | triethyl tin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | acetazolamide | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | Study on the Mechanism of Demyelination in Central Nervous System | |||||
著者 |
柳澤, 勝彦
× 柳澤, 勝彦 |
|||||
著者別名 | ||||||
識別子 | 48371 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yanagisawa, Katsuhiko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Calcium-dependent protease was extracted from human brain myelin membrane and partially purified on a phenyl Sepharose CL, 4B column. It was activated by calcium ion in the millimolar range, and therefore was determined to be calpain II. This enzyme fraction was electrophoresed and immunostained with anti-chicken muscle calpain antibody, resulting in staining as a single band with apparent molecular weight of 80K. This protease degraded exogenous myelin-associated glycoprotein. From the present result, it is suggested that calpain is bound to myelin membranes and involved in the turnover of myelin proteins. The vacuolar degeneration was produced by oral administration of triethyl tin (TET). The wet weight of brain stems which seems to reflect the degree of accumulation of water increased during the administration of the toxin, whereas the activity of 2', 3'-cyclic nucleotide 3'-phosphodiesterase altered less remarkably. When TET was withdrawed from the drinking water, the rats showed a dramatic clinical improvement along with reduction in wet weight of brain stems. Treatment with acetazolamide following TET inhibited the clinical improvement and reduction in wet weight of brain stems. The present results indicates that central myelin has plasticity in recovering from the vacuolar degeneration by removing the accumulated fluid and carbonic anhydrase is possibly involved in the dehydration of myelin in such a recovery phase. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 学位の種類: 博士(医学). 報告番号: 乙第1141号. 学位記番号: 新大医博乙第1060号. 学位授与年月日: 平成3年4月16日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新潟医学会雑誌. 1991, 105(5), 326-333. | |||||
書誌情報 | p. 1-15, 発行日 1991-04-16 | |||||
出版者 | ||||||
出版者 | 新潟大学 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1991-04-16 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101B1141 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大医博乙第1060号 |