{"_buckets": {"deposit": "237222fd-4a72-46c0-87e4-2147e4ce1472"}, "_deposit": {"id": "4391", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "4391"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00004391"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Involucrin and Filaggrin Expressions in Viral Warts : an Immunohistochemical Study"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-10-22", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "26", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "1990-10-22"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306e\u89d2\u5316\u69d8\u5f0f\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u6297involucrin\u6297\u4f53\u3068\u6297filaggrin\u6297\u4f53\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u6cd5\u3092\u884c\u3063\u305f. \u6b63\u5e38\u8868\u76ae, \u8102\u6f0f\u6027\u89d2\u5316\u75c7\u3068\u30dc\u30fc\u30a8\u30f3\u75c5\u3092\u5bfe\u7167\u3068\u3057\u305f. involucrin\u306e\u5206\u5e03\u306f, \u75a3\u8d05\u306e\u5404\u578b\u30672\u3064\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3057\u305f. \u3059\u306a\u308f\u3061, \u5c0b\u5e38\u6027\u75a3\u8d05, \u6241\u5e73\u75a3\u8d05\u3068\u5c16\u572d\u30b3\u30f3\u30b8\u30ed\u30fc\u30e0\u306e\u904e\u5f62\u6210\u8868\u76ae\u306e\u7d30\u80de\u8cea\u5185\u306b\u5747\u4e00\u306b\u67d3\u8272\u3055\u308c\u308b\u6240\u898b\u3068\u5c01\u5165\u4f53\u75a3\u8d05, \u75a3\u8d05\u72b6\u8868\u76ae\u767a\u80b2\u7570\u5e38\u75c7\u3068bowenoid papulosis\u306b\u307f\u3089\u308c\u308b\u30e2\u30b6\u30a4\u30af\u69d8\u67d3\u8272\u6240\u898b\u3067\u3042\u308b. \u7279\u306bbowenoid papulosis\u306e\u30e2\u30b6\u30a4\u30af\u69d8\u67d3\u8272\u306f\u30dc\u30fc\u30a8\u30f3\u75c5\u306e\u305d\u308c\u306b\u985e\u4f3c\u3057\u3066\u3044\u305f. \u307e\u305f, \u8102\u6f0f\u6027\u89d2\u5316\u75c7\u306f\u75a3\u8d05\u5404\u578b\u3068\u306f\u7570\u306a\u308b\u67d3\u8272\u6027\u3092\u793a\u3057\u305f. filaggrin\u306f\u75a3\u8d05\u5404\u578b\u3068\u3082, \u6b63\u5e38\u8868\u76ae, \u8102\u6f0f\u6027\u89d2\u5316\u75c7, \u30dc\u30fc\u30a8\u30f3\u75c5\u3068\u540c\u69d8\u306e\u5206\u5e03\u304a\u3088\u3073\u67d3\u8272\u6027\u3067, \u9846\u7c92\u5c64\u304a\u3088\u3073\u4e00\u90e8\u89d2\u5c64\u306b\u51fa\u73fe\u3057\u305f. \u4ee5\u4e0a\u3088\u308a, involucrin\u3068filaggrin\u306f\u3044\u305a\u308c\u3082\u89d2\u5316\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u304c, \u7279\u306binvolucrin\u306e\u767a\u73fe\u306f, \u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306e\u5404\u75c5\u578b\u5225\u306b\u307f\u3089\u308c\u308b\u89d2\u5316\u7570\u5e38\u306b\u5fdc\u3058\u305f\u5909\u5316\u3092\u793a\u3059\u3068\u8a00\u3048\u308b. \u305d\u306e\u5909\u5316\u306f\u8868\u76ae\u7d30\u80de\u306e\u5206\u5316\u306e\u7a0b\u5ea6\u3068\u95a2\u9023\u304c\u3042\u308b\u3068\u601d\u308f\u308c\u305f.", "subitem_description_type": "Abstract"}, {"subitem_description": "Involucrin and filaggrin are known to be cytologic markers for epidermal differentiation. Their expressions in the normal skin and various types of viral warts were examined using an immunoperoxidase technique. As controls seborrheic keratosis and Bowen\u0027s disease were also examined. Two different staining patterns for involucrin were observed in viral warts\uff1bverruca vulgaris, verruca plana and condyloma acuminatum showed a homogenous staining pattern, whereas bowenoid papulosis, inclusion warts and epidermodysplasia verruciformis showed a mosaic staining pattern. It was noticeable that the involucrin expression of Bowen\u0027s disease was very similar to that of bowenoid papulosis, and that seborrheic keratosis showed a very different pattern from those of viral warts. Filaggrin staining was positive in the granular cell layer and the lower part of keratinized layers in viral warts as well as in the normal epidermis, and the pattern and intensity of staining for filaggrin were the same in both. In conclusion, although filaggrin expression does not seem to be affected in viral warts, involucrin expression is changed to some distinct patterns according to the types of viral warts. The patterns seem to be related to the proliferation activities of the affected epidermis of the viral warts.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u4e59\u7b2c1104\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u533b\u535a\u4e59\u7b2c1030\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u62102\u5e7410\u670822\u65e5", "subitem_description_type": "Other"}, {"subitem_description": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c. 1990, 104(11), 946-959.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u533b\u535a\u4e59\u7b2c1030\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101B1104"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "48363", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takeshige, Masuko"}]}]}, "item_6_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66"}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7af9\u91cd, \u91cf\u5b50"}], "nameIdentifiers": [{"nameIdentifier": "48362", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "000000236423.pdf", "filesize": [{"value": "2.3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2300000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/4391/files/000000236423.pdf"}, "version_id": "1b60063a-aa02-40a6-8513-51467fec15fb"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Involucrin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Filaggrin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Viral warts", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immunohistochemistry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a4\u30f3\u30dc\u30eb\u30af\u30ea\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u514d\u75ab\u7d44\u7e54\u5316\u5b66", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306b\u304a\u3051\u308binvolucrin\u304a\u3088\u3073filaggrin\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u5c40\u5728\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306b\u304a\u3051\u308binvolucrin\u304a\u3088\u3073filaggrin\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u5c40\u5728\u306e\u691c\u8a0e"}, {"subitem_title": "\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306b\u304a\u3051\u308binvolucrin\u304a\u3088\u3073filaggrin\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u5c40\u5728\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/23482", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2013-09-26"}, "publish_date": "2013-09-26", "publish_status": "0", "recid": "4391", "relation": {}, "relation_version_is_last": true, "title": ["\u30a6\u30a4\u30eb\u30b9\u6027\u75a3\u8d05\u306b\u304a\u3051\u308binvolucrin\u304a\u3088\u3073filaggrin\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u7684\u5c40\u5728\u306e\u691c\u8a0e"], "weko_shared_id": 2}