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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Effectiveness of the quadrivalent inactivated influenza vaccine in Japan during the 2015–2016 season : A test-negative case-control study comparing the results by real time PCR, virus isolation

http://hdl.handle.net/10191/00051963
http://hdl.handle.net/10191/00051963
9a3e0a14-92cb-4f0d-9a49-c1350b20a64e
名前 / ファイル ライセンス アクション
r2nmk972.pdf 本文 (1.3 MB)
r2nmk972_a.pdf 要旨 (452.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-11-12
タイトル
タイトル Effectiveness of the quadrivalent inactivated influenza vaccine in Japan during the 2015–2016 season : A test-negative case-control study comparing the results by real time PCR, virus isolation
言語
言語 eng
キーワード
主題Scheme Other
主題 Influenza
キーワード
主題Scheme Other
主題 Influenza vaccine
キーワード
主題Scheme Other
主題 Vaccine effectiveness
キーワード
主題Scheme Other
主題 Quadrivalent inactivated vaccine (IIV4)
キーワード
主題Scheme Other
主題 Test negative case-control design
キーワード
主題Scheme Other
主題 Japan
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 2015年~2016年のインフルエンザシーズン中の日本における4価不活化インフルエンザワクチンの有効性 : リアルタイムPCR
著者 Chon, Irina

× Chon, Irina

WEKO 178231

Chon, Irina

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抄録
内容記述タイプ Abstract
内容記述 Background: We estimated influenza vaccine effectiveness (VE) in 2015–2016 season against medically attended, laboratory-confirmed influenza, when quadrivalent inactivated vaccine (IIV4) was first introduced in Japan, using test-negative case-control design. Influenza A(H1N1)pdm09 cocirculated with B/Yamagata and B/Victoria during the study period in Japan. Method: We based our case definition on two laboratory tests, real-time reverse transcription polymerase chain reaction (RT PCR), and virus isolation and compared VEs based on these tests. In addition, VE was evaluated by rapid diagnostic test (RDT). Nasopharyngeal swabs were collected from outpatients who visited clinics with influenza-like illness (ILIs) in Hokkaido, Niigata, Gunma and Nagasaki prefectures. Results: Among 713 children and adults enrolled in this study, 578 were influenza positive by RT PCR including, 392 influenza A and 186 influenza B, while 135 were tested negative controls. The adjusted VE by RT PCR for all ages against any influenza was low protection of 36.0% (95% confidence interval [CI], 3.1% to 58.6%), for influenza A was 30.0% (95% CI: 10.0% to 55.5%), and influenza B was moderate 50.2% (95% CI: 13.3% to 71.4%). Adjusted VE for virus isolation for A(H1N1)pdm09 was 37.1% (95% CI: 1.7% to 59.7%), Yamagata lineage 51.3% (95% CI: 6.4% to 74.7%) and Victoria lineage 21.3% (95% CI: 50.0% to 58.9%). VE was highest and protective in 0–5 years old group against any influenza and influenza A and B/ Yamagata, but the protective effect was not observed for other age groups and B/Victoria. RDT demonstrated concordant results with RT PCR and virus isolation. Sequencing of hemagglutinin gene showed that all A(H1N1)pdm09 belong to clade 6B including 31 strains (88.6%), which belong to clade 6B.1 possessing S162N mutations that may alter antigenicity and affect VE for A(H1N1)pdm09. Conclusions: IIV4 influenza vaccine during 2015–2016 was effective against A(H1N1)pdm09 and the two lineages of type B. Younger children was more protected than older children and adults by vaccination.
内容記述
内容記述タイプ Other
内容記述 Vaccine: X. 2019, 1, 100011.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.jvacx.2019.100011
権利
権利情報 【○!C】 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-09-23
学位授与番号
学位授与番号 13101甲第4802号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第972号
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