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Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P \u003c .02). Although most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3- infected and non-PeV-A/EV patients (P \u003c .001). Conclusions. 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Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses
http://hdl.handle.net/10191/00051958
495cd925-6934-438d-8f57-ed6c20909b71
名前 / ファイル | ライセンス | アクション | |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-11-12 | |||||
タイトル | ||||||
タイトル | Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cerebrospinal fluid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | enteroviruses | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | innate immunity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | parechovirus-A3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | serum | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | パレコウイルスA3とエンテロウイルスに感染した新生児・早期乳児の血清・髄液中の自然免疫反応 | |||||
著者 |
Habuka, Rie
× Habuka, Rie |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 178223 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | 羽深, 理恵 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P < .02). Although most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3- infected and non-PeV-A/EV patients (P < .001). Conclusions. Distinct cytokine/chemokine patterns in serum and CSF may explain the different clinical manifestations of PeVA3-infected and EV-infected neonates and young infants. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of Infectious Diseases. 2020, 222(4), 681–689. | |||||
DOI | ||||||
関連識別子 | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1093/infdis/jiaa131 | |||||
権利 | ||||||
権利情報 | 【○!C】 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-09-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4797号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第967号 |