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Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. 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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses

http://hdl.handle.net/10191/00051958
http://hdl.handle.net/10191/00051958
495cd925-6934-438d-8f57-ed6c20909b71
名前 / ファイル ライセンス アクション
r2nmk967.pdf 本文 (369.2 kB)
r2nmk967_a.pdf 要旨 (454.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-11-12
タイトル
タイトル Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses
言語
言語 eng
キーワード
主題Scheme Other
主題 cerebrospinal fluid
キーワード
主題Scheme Other
主題 enteroviruses
キーワード
主題Scheme Other
主題 innate immunity
キーワード
主題Scheme Other
主題 parechovirus-A3
キーワード
主題Scheme Other
主題 serum
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル パレコウイルスA3とエンテロウイルスに感染した新生児・早期乳児の血清・髄液中の自然免疫反応
著者 Habuka, Rie

× Habuka, Rie

WEKO 178222

Habuka, Rie

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著者別名
識別子 178223
識別子Scheme WEKO
姓名 羽深, 理恵
抄録
内容記述タイプ Abstract
内容記述 Background. Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P < .02). Although most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3- infected and non-PeV-A/EV patients (P < .001). Conclusions. Distinct cytokine/chemokine patterns in serum and CSF may explain the different clinical manifestations of PeVA3-infected and EV-infected neonates and young infants.
内容記述
内容記述タイプ Other
内容記述 The Journal of Infectious Diseases. 2020, 222(4), 681–689.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1093/infdis/jiaa131
権利
権利情報 【○!C】 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-09-23
学位授与番号
学位授与番号 13101甲第4797号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第967号
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