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Serum Anti-interferon-γ Autoantibody Titer as a Potential Biomarker of Disseminated Non-tuberculous Mycobacterial Infection
http://hdl.handle.net/10191/00051957
http://hdl.handle.net/10191/000519573d75d581-d7f3-49c6-b2ba-af5a6debb4f2
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本文 (586.3 kB)
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要旨 (452.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-11-12 | |||||
| タイトル | ||||||
| タイトル | Serum Anti-interferon-γ Autoantibody Titer as a Potential Biomarker of Disseminated Non-tuberculous Mycobacterial Infection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Disseminated NTM | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neutralizing capacity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | biomarker | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | serum interferon-γ autoantibody titer | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 播種性非結核性抗酸菌症における抗インターフェロンγ自己抗体のバイオマーカーとしての役割 | |||||
| 著者 |
Yoshizawa, Kazutaka
× Yoshizawa, Kazutaka |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 178221 | |||||
| 姓名 | 吉澤, 和孝 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose In the past decade, the relationship between naturally occurring interferon-γ-neutralizing autoantibodies (IFNγ-Ab) and disseminated non-tuberculous mycobacteria (NTM) infection has been established. Furthermore, immune suppressive therapy aimed at the suppression of antibody production has shown efficacy as a supportive treatment. However, the nature of antibody behavior and antibody titer during the course of this disease, as well as the pathophysiological significance of IFNγ-Ab, has not yet been fully elucidated. Methods Thirteen Japanese subjects suffering from disseminated NTM (dNTM) infection with IFNγ-Ab were evaluated. The fluctuation of IFNγ-Ab titer and the neutralizing capacity against IFN-γ during the course of the disease were retrospectively analyzed. IFNγ-Ab titers in the sera were quantified using an enzyme-linked immunosorbent assay; neutralizing capacity was evaluated via flow cytometry. Results Serum antibody titers were not constant during the treatment period and varied over the course of the disease. The antibody titer decreased when the disease was improved by anti-mycobacterial treatment (p < 0.01) and increased as the disease progressed (p < 0.05). Even after the antibody titer decreased, the neutralizing capacity against IFN-γ was maintained by individual sera. Conclusions Despite the improvement in the pathological condition via treatment, the patients’ sera maintained neutralizing capacity against IFN-γ. Antibody titer fluctuated over the course of the disease and exhibited potential as a biomarker for judgment of the disease state. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Clinical Immunology. 2020, 40, 399–405. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1007/s10875-020-00762-1 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 Springer Science+Business Media, LLC, part of Springer Nature 2020 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-09-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4796号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(医)甲第966号 | |||||
