{"_buckets": {"deposit": "13a21760-126f-4d9a-bd6c-55fdf40d70d1"}, "_deposit": {"id": "34147", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "34147"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00034147", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "メチオニン・コリン欠乏食、高脂肪食による脂肪性肝炎マウスにおけるミトコンドリア恒常性への影響"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2020-09-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models. Inspired by the fact that mitochondrial (mt)DNA content is changed in non-alcoholic fatty liver disease in humans, we investigated the mtDNA copy number in the NASH mice models induced by high-fat diet (HFD) and methionine/choline-deficient diet (MCD) to understand the differences between these models. Megamitochondria were observed in both MCD and HFD groups. However, the MCD group showed significant decrease in liver mtDNA content compared with that in the HFD group. These changes were associated with significant upregulation of mitochondrial biogenesis- and degradation-related genes in MCD model than in HFD model. Thus, stability of mtDNA is associated with the differences between MCD and HFD-induced NASH models often used in studies; these findings could help in choosing appropriate models for studies on NASH.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Biochemical and Biophysical Research Communications. 2020, 527(2), 365-371.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第954号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4784号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "178197", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "荒生, 祥尚"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.bbrc.2020.03.180", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2020 Elsevier Inc. All rights reserved."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Arao, Yoshihisa"}], "nameIdentifiers": [{"nameIdentifier": "178196", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2nmk954.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/34147/files/r2nmk954.pdf"}, "version_id": "96962c06-d521-4ca8-a050-b71c66bd268a"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-11-12"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2nmk954_a.pdf", "filesize": [{"value": "456.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 456400.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/34147/files/r2nmk954_a.pdf"}, "version_id": "899bd724-527b-4362-9fd9-8027b8768e30"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Methionine/choline-deficient diet", "subitem_subject_scheme": "Other"}, {"subitem_subject": "High-fat diet", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mitochondrial biogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mitochondrial degradation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mitochondrial DNA copy Number", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stress", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051945", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-11-12"}, "publish_date": "2020-11-12", "publish_status": "0", "recid": "34147", "relation": {}, "relation_version_is_last": true, "title": ["Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice"], "weko_shared_id": null}