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Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice
http://hdl.handle.net/10191/00051945
http://hdl.handle.net/10191/00051945806a4a35-c863-4b06-b60d-18f13de26829
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本文 (1.8 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-11-12 | |||||
タイトル | ||||||
タイトル | Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methionine/choline-deficient diet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-fat diet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondrial biogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondrial degradation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondrial DNA copy Number | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxidative stress | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | メチオニン・コリン欠乏食、高脂肪食による脂肪性肝炎マウスにおけるミトコンドリア恒常性への影響 | |||||
著者 |
Arao, Yoshihisa
× Arao, Yoshihisa |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 178197 | |||||
姓名 | 荒生, 祥尚 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models. Inspired by the fact that mitochondrial (mt)DNA content is changed in non-alcoholic fatty liver disease in humans, we investigated the mtDNA copy number in the NASH mice models induced by high-fat diet (HFD) and methionine/choline-deficient diet (MCD) to understand the differences between these models. Megamitochondria were observed in both MCD and HFD groups. However, the MCD group showed significant decrease in liver mtDNA content compared with that in the HFD group. These changes were associated with significant upregulation of mitochondrial biogenesis- and degradation-related genes in MCD model than in HFD model. Thus, stability of mtDNA is associated with the differences between MCD and HFD-induced NASH models often used in studies; these findings could help in choosing appropriate models for studies on NASH. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biochemical and Biophysical Research Communications. 2020, 527(2), 365-371. | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.bbrc.2020.03.180 | |||||
権利 | ||||||
権利情報 | 【○!C】 2020 Elsevier Inc. All rights reserved. | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-09-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4784号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第954号 |