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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice

http://hdl.handle.net/10191/00051945
http://hdl.handle.net/10191/00051945
806a4a35-c863-4b06-b60d-18f13de26829
名前 / ファイル ライセンス アクション
r2nmk954.pdf 本文 (1.8 MB)
r2nmk954_a.pdf 要旨 (456.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-11-12
タイトル
タイトル Effect of methionine/choline-deficient diet and high-fat diet-induced steatohepatitis on mitochondrial homeostasis in mice
言語
言語 eng
キーワード
主題Scheme Other
主題 Methionine/choline-deficient diet
キーワード
主題Scheme Other
主題 High-fat diet
キーワード
主題Scheme Other
主題 Mitochondrial biogenesis
キーワード
主題Scheme Other
主題 Mitochondrial degradation
キーワード
主題Scheme Other
主題 Mitochondrial DNA copy Number
キーワード
主題Scheme Other
主題 Oxidative stress
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル メチオニン・コリン欠乏食、高脂肪食による脂肪性肝炎マウスにおけるミトコンドリア恒常性への影響
著者 Arao, Yoshihisa

× Arao, Yoshihisa

WEKO 178196

Arao, Yoshihisa

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著者別名
識別子 178197
識別子Scheme WEKO
姓名 荒生, 祥尚
抄録
内容記述タイプ Abstract
内容記述 Considering the increase in cases of non-alcoholic steatohepatitis (NASH), the use of appropriate animal model of NASH is essential to understand the underlying pathogenesis mechanism. To date, several mice models have been used; however, significant differences in the etiologies and food administered affected the results, with inconsistent conclusions. Therefore, it is necessary to understand these models and their differences to be able to choose appropriate models. Inspired by the fact that mitochondrial (mt)DNA content is changed in non-alcoholic fatty liver disease in humans, we investigated the mtDNA copy number in the NASH mice models induced by high-fat diet (HFD) and methionine/choline-deficient diet (MCD) to understand the differences between these models. Megamitochondria were observed in both MCD and HFD groups. However, the MCD group showed significant decrease in liver mtDNA content compared with that in the HFD group. These changes were associated with significant upregulation of mitochondrial biogenesis- and degradation-related genes in MCD model than in HFD model. Thus, stability of mtDNA is associated with the differences between MCD and HFD-induced NASH models often used in studies; these findings could help in choosing appropriate models for studies on NASH.
内容記述
内容記述タイプ Other
内容記述 Biochemical and Biophysical Research Communications. 2020, 527(2), 365-371.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.bbrc.2020.03.180
権利
権利情報 【○!C】 2020 Elsevier Inc. All rights reserved.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-09-23
学位授与番号
学位授与番号 13101甲第4784号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第954号
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