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Clinicopathological analysis of splenic red pulp low grade B-cell lymphoma
http://hdl.handle.net/10191/00051830
http://hdl.handle.net/10191/000518305db53149-bd65-4013-87e3-5000ad03e444
名前 / ファイル | ライセンス | アクション |
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本文 (695.3 kB)
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要旨 (572.6 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-08-31 | |||||
タイトル | ||||||
タイトル | Clinicopathological analysis of splenic red pulp low grade B-cell lymphoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Splenic B-cell lymphoma/leukemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unclassifiable | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hairy cell leukemia-variant | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BRAF mutation (V600E) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclin D3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cyclin D1 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 脾臓赤脾髄原発低悪性度B細胞性リンパ腫の臨床病理学的解析 | |||||
著者 |
Suzuki, Takaharu
× Suzuki, Takaharu |
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著者別名 | ||||||
識別子 | 178063 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鈴木, 隆晴 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Primary splenic low-grade B-cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and splenic B-cell lymphoma/leukemia, unclassifiable (SPLL-U). SPLL-U is a rare disease that includes subtypes of a hairy cell leukemia-variant (HCL-v), splenic diffuse red pulp small B-cell lymphoma (SDRPL), and other types that are known as narrow-sense SPLL-U (SPLL-U-NS). Notably, limited information is available regarding the BRAF mutation (V600E) and cyclin D3 expression in subtypes of SPLL-U. Therefore, we performed a pathological analysis of the BRAF mutation (V600E) and characterized pathological features of SPLL-U. We reviewed the pathological findings of 12 SPLL-U cases. The 12 cases considered included 2 cases of HCL-v, 6 cases of SPLLU-NS, and 4 undetermined cases. The BRAF mutation (V600E) was detected in 3 cases, which were all SPLL-U-NS. Cases with the BRAF mutation (V600E) have increased levels of CD103 expression and decreased cyclin D3 and cyclin D1 expression compared with cases that lacked the BRAF mutation. These findings suggest that the BRAF mutation might play a significant role in SPLL-U. Therefore, the significance of the BRAF mutation should be evaluated via genomic or transcriptional analyses of a large cohort of SPLL-U patients. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Pathology International. 2020, 70(5), 280-286. | |||||
書誌情報 | p. 1-15 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/pin.12909 | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4707号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第941号 |