{"_buckets": {"deposit": "94ae5359-b5ea-4b4a-b700-5ae9c71c0087"}, "_deposit": {"id": "34024", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "34024"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00034024", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "ゲムシタビンはミトコンドリア常在性E3ユビキチンリガーゼMUL1を介してPINK1を安定化しParkin非依存性マイトファジーを誘導する"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2020-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Mitophagy plays an important role in the maintenance of mitochondrial homeostasis. PTEN-induced kinase (PINK1), a key regulator of mitophagy, is degraded constitutively under steady-state conditions. During mitophagy, it becomes stabilized in the outer mitochondrial membrane, particularly under mitochondrial stress conditions, such as in treatment with uncouplers, generation of excessive mitochondrial reactive oxygen species, and formation of protein aggregates in mitochondria. StabilizedPINK1 recruits and activates E3 ligases, such as Parkin and mitochondrial ubiquitin ligase (MUL1), to ubiquitinate mitochondrial proteins and induce ubiquitin-mediated mitophagy. Here, we found that the anticancer drug gemcitabine induces the stabilization of PINK1 and subsequent mitophagy, even in the absence of Parkin. We also found that gemcitabine-induced stabilization of PINK1 was not accompanied by mitochondrial depolarization. Interestingly, the stabilization of PINK1 was mediated by MUL1. These results suggest that gemcitabine induces mitophagy through MUL1-mediated stabilization of PINK1 on the mitochondrial membrane independently of mitochondrial depolarization.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Scientific Reports. 2020, 10, 1465", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第933号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4699号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "178047", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "五十嵐, 遼子"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41598-020-58315-w", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Igarashi, Ryoko"}], "nameIdentifiers": [{"nameIdentifier": "178046", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk933.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/34024/files/r1nmk933.pdf"}, "version_id": "422e167a-f921-4d08-a9bb-391f7c3d5860"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk933_a.pdf", "filesize": [{"value": "570.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 570600.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/34024/files/r1nmk933_a.pdf"}, "version_id": "08786777-3413-4adf-9bde-eae4dc7141eb"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Gemcitabine induces Parkinindependent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Gemcitabine induces Parkinindependent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051822", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-08-31"}, "publish_date": "2020-08-31", "publish_status": "0", "recid": "34024", "relation": {}, "relation_version_is_last": true, "title": ["Gemcitabine induces Parkinindependent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1"], "weko_shared_id": null}