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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Gemcitabine induces Parkinindependent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1

http://hdl.handle.net/10191/00051822
http://hdl.handle.net/10191/00051822
a1268390-d881-4914-a2ee-e479f7e1819c
名前 / ファイル ライセンス アクション
r1nmk933.pdf 本文 (1.8 MB)
r1nmk933_a.pdf 要旨 (570.6 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-08-31
タイトル
タイトル Gemcitabine induces Parkinindependent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル ゲムシタビンはミトコンドリア常在性E3ユビキチンリガーゼMUL1を介してPINK1を安定化しParkin非依存性マイトファジーを誘導する
著者 Igarashi, Ryoko

× Igarashi, Ryoko

WEKO 178046

Igarashi, Ryoko

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著者別名
識別子 178047
識別子Scheme WEKO
姓名 五十嵐, 遼子
抄録
内容記述タイプ Abstract
内容記述 Mitophagy plays an important role in the maintenance of mitochondrial homeostasis. PTEN-induced kinase (PINK1), a key regulator of mitophagy, is degraded constitutively under steady-state conditions. During mitophagy, it becomes stabilized in the outer mitochondrial membrane, particularly under mitochondrial stress conditions, such as in treatment with uncouplers, generation of excessive mitochondrial reactive oxygen species, and formation of protein aggregates in mitochondria. StabilizedPINK1 recruits and activates E3 ligases, such as Parkin and mitochondrial ubiquitin ligase (MUL1), to ubiquitinate mitochondrial proteins and induce ubiquitin-mediated mitophagy. Here, we found that the anticancer drug gemcitabine induces the stabilization of PINK1 and subsequent mitophagy, even in the absence of Parkin. We also found that gemcitabine-induced stabilization of PINK1 was not accompanied by mitochondrial depolarization. Interestingly, the stabilization of PINK1 was mediated by MUL1. These results suggest that gemcitabine induces mitophagy through MUL1-mediated stabilization of PINK1 on the mitochondrial membrane independently of mitochondrial depolarization.
内容記述
内容記述タイプ Other
内容記述 Scientific Reports. 2020, 10, 1465
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/s41598-020-58315-w
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-03-23
学位授与番号
学位授与番号 13101甲第4699号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第933号
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