WEKO3
アイテム
Change in body composition in patients with achalasia before and after peroral endoscopic myotomy
http://hdl.handle.net/10191/00051804
http://hdl.handle.net/10191/00051804b178f73a-0bcc-4c9e-b8fe-312030affa01
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-08-31 | |||||
タイトル | ||||||
タイトル | Change in body composition in patients with achalasia before and after peroral endoscopic myotomy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | abdominal fat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | achalasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bioelectrical impedance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroral endoscopic myotomy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | skeletal muscle | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 食道アカラシア患者における内視鏡的筋層切開術前後での体組成変化の検討 | |||||
著者 |
Mizusawa, Takeshi
× Mizusawa, Takeshi |
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著者別名 | ||||||
識別子 | 178012 | |||||
識別子Scheme | WEKO | |||||
姓名 | 水澤, 健 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background and Aim: Patients with achalasia experience weight loss because of dysphagia caused by impaired relaxation of the lower esophageal sphincter. This study aimed to use dual bioelectrical impedance analysis (BIA) to determine the change in bodyweight and body composition in patients with achalasia before and after peroral endoscopic myotomy (POEM). Methods: Patients with achalasia who underwent POEM from 2013 to 2018 (n = 72) were retrospectively analyzed for change in bodyweight before and after 3 months. Additionally, change in body composition was prospectively investigated in the final 10 of 72 patients using non-radiation dual BIA. Results: Twenty patients (27.8%) were underweight (body mass index < 18.5) before undergoing POEM. No clinical parameters were identified to be associated with the underweight condition before POEM and be predictive of an increase in bodyweight after POEM. Low visceral fat volume observed on dual BIA correlated closely with the result obtained using computed tomography (Pearson correlation coefficient: r = 0.850, P < 0.01). Patients with achalasia had a statistically significant increase in visceral (P < 0.01) and subcutaneous fat volumes (P < 0.01) after POEM. Skeletal muscle mass index slightly increased (P = 0.02), although the value after POEM was still low. No blood biomarkers were indicators for low bodyweight or low visceral fat volume. Conclusions: Dual BIA is an effective non-invasive tool to evaluate the change in body composition of underweight patients with achalasia. Skeletal muscle volume was not enough after POEM, although a rapid increase in the intra-abdominal fat volume was observed. Additional studies are warranted to understand the pathological implications. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Gastroenterology and Hepatology. 2020, 35(4), 601-608. | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/jgh.14847 | |||||
権利 | ||||||
権利情報 | 【○!C】 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2020-03-23 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4681号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第915号 |