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The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes : a prospective observation study : a prospective observation study
http://hdl.handle.net/10191/00051802
http://hdl.handle.net/10191/00051802e33958ec-00b4-4ad6-af09-23a541c92c82
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本文 (2.4 MB)
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要旨 (571.8 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-08-31 | |||||
| タイトル | ||||||
| タイトル | The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes : a prospective observation study : a prospective observation study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | brain metastasis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | health-related quality of life | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | neurocognitive function | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | whole brain radiation therapy | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 健康関連QOL変化を参考にした脳転移全脳照射後の認知機能変化 | |||||
| 著者 |
Nakano, Toshimichi
× Nakano, Toshimichi |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 178008 | |||||
| 姓名 | 中野, 智成 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. Methods: We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain showed changes that exceeded the cut-off while other domains remained stable. The remaining patients were categorized as stable, and the patients who showed both significant improvement and deterioration were categorized as 'both.' We examined the clinical meaning of NCF changes using the cut-off values 1.0, 1.5, and 2.0SD based on the percentage of patients whose HR-QOL changes were ≥10 points. Results: Baseline, 4-month and 8-month data were available in 78, 41 (compliance; 85%), and 29 (81%) patients, respectively. At 4 months, improvement/stable/deterioration/both was seen in 15%/12%/41%/32% of the patients when 1.0 SD was used; 19%/22%/37%/22% with1.5 SD, and 17%/37%/37%/9% with 2.0 SD. The HR-QOL scores on the QLQ-C30 functional scale were significantly worse in the deterioration group versus the others with 1.0SD (p=0.013) and 1.5 SD (p=0.015). With 1.5 SD, the HR-QOL scores on the QLQ-BN20was significantly better in the improvement group versus the others (p=0.033). However, when 'both' was included in 'improvement' or 'deterioration,' no significant difference in HRQOL was detected. Conclusions: The NCF cut-off of 1.5 SD and the exclusion of 'both' patients from the 'deterioration' and 'improvement' groups best reflects HR-QOL changes. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | BMC Cancer. 2020, 20(1), 66. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1186/s12885-020-6559-3 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4679号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(医)甲第913号 | |||||
