{"_buckets": {"deposit": "e2d30923-d1a2-463a-b219-a5927042e865"}, "_deposit": {"id": "34001", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "34001"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00034001"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Identification of miRNAs in exosomes from human glial hybrid cell line with cytoplasmic alpha-synuclein inclusions"}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2020-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb(\u533b\u5b66)"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u8fd1\u5e74\uff0c\u591a\u7cfb\u7d71\u840e\u7e2e\u75c7 (multiple system atrophy; MSA) \u306e\u8a3a\u65ad\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\uff0c\u60a3\u8005\u8840\u6db2\u3084\u8133\u810a\u9ac4\u6db2\u4e2d\u306e\u30de\u30a4\u30af\u30ed RNA (micro RNA; miRNA) \u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\uff0e\u3057\u304b\u3057\uff0c\u65e9\u671f\u8a3a\u65ad\u306e\u70ba\u306b\u306f\uff0c\u7f79\u60a3\u7d30\u80de\u306e\u7d30\u80de\u6b7b\u306b\u3088\u308b\u526f\u6b21\u7684\u306a\u5909\u5316\u3092\u9664\u5916\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e\u305d\u3053\u3067\uff0c\u7f79\u60a3\u7d30\u80de\u304c\u7d30\u80de\u6b7b\u306b\u81f3\u308b\u524d\u306e\u75c5\u614b\u3092\u53cd\u6620\u3057\u305f miRNA\u3092\u89e3\u6790\u3059\u308b\u8a66\u6599\u3068\u3057\u3066\uff0c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0 (exosome) \u306b\u7740\u76ee\u3057\u305f\uff0e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\uff0c\u7d30\u80de\u5916\u5c0f\u80de (small extracellular vesicle; sEV) \u306e 1 \u7a2e\u3067\u3042\u308a\uff0c\u5185\u90e8\u306e\u7269\u8cea\u306f\u5206\u6ccc\u7d30\u80de\u306e\u74b0\u5883\u3092\u53cd\u6620\u3059\u308b\uff0eMSA \u3067\u306f\uff0c\u4e3b\u306b\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u306b\u3066 \u03b1 \u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u306e\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u3092\u8a8d\u3081\u308b\u3053\u3068\u304b\u3089\uff0c\u307e\u305a\uff0c\u3053\u306e\u75c5\u614b\u3092\u53cd\u6620\u3059\u308b\u7d30\u80de\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3057\uff0c\u305d\u306e\u7d30\u80de\u7531\u6765\u306e\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u306b\u7279\u5fb4\u7684\u306amiRNA\u304c\u5b58\u5728\u3059\u308b\u304b\u5426\u304b\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\uff0e\u30d2\u30c8\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cfb\u57f9\u990a\u7d30\u80de\u306b\u304a\u3044\u3066\uff0c\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u907a\u4f1d\u5b50\u3068\u7dda\u7dad\u5316 \u03b1 \u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u86cb\u767d\u3092\u5171\u5c0e\u5165\u3057\uff0c\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u3092\u5f62\u6210\u3057\u305f\uff0e\u305d\u306e\u969b\u306e\u7d30\u80de\u57f9\u990a\u57f9\u5730\u304b\u3089\uff0c\u8d85\u9060\u5fc3\u6cd5\u3092\u7528\u3044\u3066\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u542b\u3080 sEV\u5206\u753b\u3092\u5206\u96e2\u3057\u305f\uff0e\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u5c01\u5165\u4f53\u5f62\u6210\u306e\u6709\u7121\u306e 2 \u7fa4\u306b\u304a\u3044\u3066\uff0csEV \u5206\u753b\u304b\u3089\u62bd\u51fa\u3057\u305f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0 RNA \u306b\u3064\u3044\u3066\uff0c\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u306b\u3088\u308a\uff0c2,578 \u7a2e\u985e\u306e miRNA \u306e\u767a\u73fe\u91cf\u3092\u89e3\u6790\u3057\u305f\uff0e\u4e21\u7fa4\u306e\u3044\u305a\u308c\u304b\u3067\u767a\u73fe\u3092\u8a8d\u3081\u305f miRNA \u306f1,036 \u7a2e\u985e\u3042\u308a\uff0c\u4e21\u7fa4\u9593\u3067\u767a\u73fe\u91cf\u306b\u7d71\u8a08\u5b66\u7684\u6709\u610f\u5dee\u3092\u8a8d\u3081\u305f miRNA \u306f 117 \u7a2e\u985e\u3067\u3042\u3063\u305f\uff0e\u3053\u308c\u3089\u3092\u7528\u3044\u968e\u5c64\u30af\u30e9\u30b9\u30bf\u30fc\u5206\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\uff0c\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u5c01\u5165\u4f53\u5f62\u6210\u306e\u6709\u7121\u306b\u5206\u985e\u3067\u304d\u305f\uff0e\u307e\u305f\uff0c\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u5f62\u6210\u6642\u306b\uff0c2 \u500d\u4ee5\u4e0a\u306e\u767a\u73fe\u5909\u5316\u3092\u8a8d\u3081\u305f miRNA \u306f 29 \u7a2e\u985e\u3042\u308a\uff0c28 \u7a2e\u985e\u304c\u5897\u52a0\uff0c1\u7a2e\u985e\u304c\u6e1b\u5c11\u3057\u3066\u3044\u305f\uff0e\u3053\u306e\u5185\uff0cMSA \u60a3\u8005\u4f53\u6db2\u4e2d\u3067\u767a\u73fe\u5909\u5316\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\uff0c\u6319\u52d5\u304c\u4e00\u81f4\u3057\u3066\u3044\u305f\u306e\u306f\uff0c\u767a\u73fe\u304c\u5897\u52a0\u3057\u305fhsa-miR-663a \u306e\u307f\u3067\u3042\u3063\u305f\uff0e\u3055\u3089\u306b\uff0cMSA\u60a3\u8005\u306b\u304a\u3044\u3066\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308bgamma aminobutyric acid A receptor associated protein \u306b\u5bfe\u3059\u308bmiRNA\uff12\u7a2e\u985e\u3092\u306f\u3058\u3081\uff0c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u969c\u5bb3\u3084\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u30df\u30b9\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u3068\u306e\u95a2\u4e0e\u304c\u793a\u5506\u3055\u308c\u308b miRNA \u306e\u5897\u52a0\u306a\u3069\uff0cMSA \u75c5\u614b\u306e\u89e3\u660e\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b miRNA \u306e\u5909\u5316\u3092\u898b\u51fa\u3057\u305f\uff0e\u672c\u7814\u7a76\u3067\u306f\uff0c\u30d2\u30c8\u30aa\u30ea\u30b4\u30c7\u30f3\u30c9\u30ed\u30b5\u30a4\u30c8\u7cfb\u57f9\u990a\u7d30\u80de\u306b\u304a\u3044\u3066\uff0c\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u5185\u5c01\u5165\u4f53\u5f62\u6210\u6642\u306b\uff0c\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u306b\u7279\u7570\u7684\u306a miRNA \u767a\u73fe\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f\uff0e\u3053\u306e\u5909\u5316\u306f\uff0c\u4eca\u5f8c\uff0c\u30d2\u30c8\u60a3\u8005\u7d44\u7e54\u3084\u4f53\u6db2\u691c\u4f53\u306b\u3066\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e\u307e\u305f\uff0c\u672c\u7814\u7a76\u306b\u304a\u3044\u3066\u78ba\u7acb\u3057\u305f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u5206\u96e2\u304a\u3088\u3073\u30a8\u30af\u30bd\u30bd\u30fc\u30e0 RNA \u306e\u62bd\u51fa\u624b\u6280\u306f\uff0c\u69d8\u3005\u306a\u691c\u4f53\u306b\u5fdc\u7528\u304c\u53ef\u80fd\u3067\u3042\u308a\uff0cMSA \u4ee5\u5916\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3082\u5bfe\u8c61\u3068\u3057\u3046\u308b\uff0e\u3053\u306e\u624b\u6280\u3092\u7528\u3044\uff0c\u75be\u60a3\u7279\u7570\u7684\u306a\u8a3a\u65ad\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u958b\u767a\u3084\u75c5\u614b\u89e3\u660e\u3092\u9032\u3081\u3066\u3044\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u308b\uff0e", "subitem_description_type": "Abstract"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a(\u533b)\u7532\u7b2c910\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c4676\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "178002", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kasahara, Sou"}]}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7b20\u539f, \u58ee"}], "nameIdentifiers": [{"nameIdentifier": "178001", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk910.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/34001/files/r1nmk910.pdf"}, "version_id": "1c40a817-04e8-41d7-9169-e3971f855556"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk910_a.pdf", "filesize": [{"value": "571.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 571500.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/34001/files/r1nmk910_a.pdf"}, "version_id": "25dbe65e-9c0e-4bbe-89fc-7d3c0396e97f"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "\u591a\u7cfb\u7d71\u840e\u7e2e\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a8\u30af\u30bd\u30bd\u30fc\u30e0", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30de\u30a4\u30af\u30edRNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u5f62\u6210\u6642\u306b\u8a98\u5c0e\u3055\u308c\u308b\u30d2\u30c8\u30b0\u30ea\u30a2\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u30de\u30a4\u30af\u30edRNA\u306e\u540c\u5b9a", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u5f62\u6210\u6642\u306b\u8a98\u5c0e\u3055\u308c\u308b\u30d2\u30c8\u30b0\u30ea\u30a2\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u30de\u30a4\u30af\u30edRNA\u306e\u540c\u5b9a"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/00051799", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2020-08-31"}, "publish_date": "2020-08-31", "publish_status": "0", "recid": "34001", "relation": {}, "relation_version_is_last": true, "title": ["\u03b1-\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u967d\u6027\u7d30\u80de\u8cea\u5185\u5c01\u5165\u4f53\u5f62\u6210\u6642\u306b\u8a98\u5c0e\u3055\u308c\u308b\u30d2\u30c8\u30b0\u30ea\u30a2\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u5185\u30de\u30a4\u30af\u30edRNA\u306e\u540c\u5b9a"], "weko_shared_id": null}