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Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth
http://hdl.handle.net/10191/00051760
http://hdl.handle.net/10191/00051760db58d58e-432c-4be6-bd5e-6a09bd4d5c17
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本文 (865.3 kB)
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要旨 (258.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-08-31 | |||||
| タイトル | ||||||
| タイトル | Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Epithelial cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Guinea pig | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Molar | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Stem cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Three-dimensional imaging | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | モルモット臼歯における上皮幹細胞ニッチを含む形成端上皮コンパートメントの三次元立体構築 | |||||
| 著者 |
Seino, Yuta
× Seino, Yuta |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177949 | |||||
| 姓名 | 清野, 雄多 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Continuously growing rodent incisors have an apically located epithelial stem cell compartment, known as an “apical bud” (AB). Few studies have described the morphological features of ABs and stem cell niches in continuously growing premolars/molars. We attempted to clarify the relationship between the three-dimensional configuration of ABs and the stem cell niches in guinea pig cheek teeth. Methods: We perfusion-fixed four-week-old guinea pigs, then decalcified their premolars/molars to produce serial paraffin sections, which we immunostained for Sox2. We reconstructed the serial sections using image processing and analysis software. We processed undecalcified samples for scanning electron microscopy by KOH digestion. Results: Two types of epithelia with M and Δ shapes surrounded the S-shaped dental papilla in the apical region of the premolars/molars, and there were three Sox2-positive epithelial bulges above the M andΔ-shaped epithelia. Sox2-positive epithelial stem cell niches were restricted to the apical side, and cell proliferation and differentiation immediately proceeded in the crown-analogue dentin. The Sox2-positive epithelial stem cell niches were sparsely distributed and extended to the occlusal side. We also detected continuously proliferating cells in the cervical loop and Hertwig’s epithelial root sheath of the root-analogue dentin. Conclusions: Our findings suggest that guinea pig cheek teeth have three ABs, and the complex configuration of these types of teeth may be attributed to the prompt formation of crown-analogue dentin followed by the long-term formation of root-analogue dentin. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Oral Biosciences. 2019, 61(1), 55-63. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.job.2019.01.002 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 2019 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4743号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(歯)甲第467号 | |||||
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Seino, Yuta, n.d., Three-dimensional configuration of apical epithelial compartments including stem cell niches in guinea pig cheek teeth.
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