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  1. 260 大学院医歯学総合研究科(歯)
  2. 60 博士学位論文
  3. 10 博士学位論文
  1. 0 資料タイプ別
  2. 02 学位論文

Primary cilia in murine palatal rugae development

http://hdl.handle.net/10191/00051742
http://hdl.handle.net/10191/00051742
87474fbe-336f-4da7-a323-2f1350a2f0e0
名前 / ファイル ライセンス アクション
r1ndk449.pdf 本文 (5.1 MB)
r1ndk449_a.pdf 要旨 (204.4 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-08-31
タイトル
タイトル Primary cilia in murine palatal rugae development
言語
言語 eng
キーワード
主題Scheme Other
主題 Palatal rugae development
キーワード
主題Scheme Other
主題 Shh
キーワード
主題Scheme Other
主題 Non-canonical Wnt
キーワード
主題Scheme Other
主題 Primary cilia
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル マウス口蓋皺壁発生における一次繊毛の役割
著者 Nakaniwa, Mayuko

× Nakaniwa, Mayuko

WEKO 177917

Nakaniwa, Mayuko

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著者別名
識別子 177918
識別子Scheme WEKO
姓名 中庭, 麻友子
抄録
内容記述タイプ Abstract
内容記述 Periodic patterning of iterative structures is a fundamental process during embryonic development, since these structures are diverse across the animal kingdom. Therefore, elucidating the molecular mechanisms in the formation of these structures promotes understanding of the process of organogenesis. Periodically patterned ridges, palatal rugae (situated on the hard palate of mammals), are an excellent experimental model to clarify the molecular mechanisms involved in the formation of periodic patterning of iterative structures. Primary cilia are involved in many biological events, including the regulation of signaling pathways such as Shh and non-canonical Wnt signaling. However, the role of primary cilia in the development of palatal rugae remains unclear. We found that primary cilia were localized to the oral cavity side of the interplacode epithelium of the palatal rugae, whereas restricted localization of primary cilia could not be detected in other regions. Next, we generated mice with a placodal conditional deletion of the primary cilia protein Ift88, using ShhCre mice (Ift88^<fl/fl>;ShhCre). Highly disorganized palatal rugae were observed in Ift88^<fl/fl>;ShhCre mice. Furthermore, by comparative in situ hybridization analysis, many Shh and non-canonical Wnt signaling-related molecules showed spatiotemporal expression patterns during palatal rugae development, including restricted expression in the epithelium (placodes and interplacodes) and mesenchyme. Some of these expression were found to be altered in Ift88^<fl/fl>;ShhCre mice. Primary cilia is thus involved in development of palatal rugae.
内容記述
内容記述タイプ Other
内容記述 Gene Expression Patterns. 2019, 34, 119062.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.gep.2019.119062
権利
権利情報 【○!C】 2019 Elsevier B.V. All rights reserved.
著者版フラグ
値 ETD
学位名
学位名 博士(歯学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2020-03-23
学位授与番号
学位授与番号 13101甲第4725号
学位記番号
内容記述タイプ Other
内容記述 新大院博(歯)甲第449号
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