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Primary cilia in murine palatal rugae development
http://hdl.handle.net/10191/00051742
http://hdl.handle.net/10191/0005174287474fbe-336f-4da7-a323-2f1350a2f0e0
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本文 (5.1 MB)
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要旨 (204.4 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-08-31 | |||||
| タイトル | ||||||
| タイトル | Primary cilia in murine palatal rugae development | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Palatal rugae development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Shh | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Non-canonical Wnt | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Primary cilia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | マウス口蓋皺壁発生における一次繊毛の役割 | |||||
| 著者 |
Nakaniwa, Mayuko
× Nakaniwa, Mayuko |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177918 | |||||
| 姓名 | 中庭, 麻友子 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Periodic patterning of iterative structures is a fundamental process during embryonic development, since these structures are diverse across the animal kingdom. Therefore, elucidating the molecular mechanisms in the formation of these structures promotes understanding of the process of organogenesis. Periodically patterned ridges, palatal rugae (situated on the hard palate of mammals), are an excellent experimental model to clarify the molecular mechanisms involved in the formation of periodic patterning of iterative structures. Primary cilia are involved in many biological events, including the regulation of signaling pathways such as Shh and non-canonical Wnt signaling. However, the role of primary cilia in the development of palatal rugae remains unclear. We found that primary cilia were localized to the oral cavity side of the interplacode epithelium of the palatal rugae, whereas restricted localization of primary cilia could not be detected in other regions. Next, we generated mice with a placodal conditional deletion of the primary cilia protein Ift88, using ShhCre mice (Ift88^<fl/fl>;ShhCre). Highly disorganized palatal rugae were observed in Ift88^<fl/fl>;ShhCre mice. Furthermore, by comparative in situ hybridization analysis, many Shh and non-canonical Wnt signaling-related molecules showed spatiotemporal expression patterns during palatal rugae development, including restricted expression in the epithelium (placodes and interplacodes) and mesenchyme. Some of these expression were found to be altered in Ift88^<fl/fl>;ShhCre mice. Primary cilia is thus involved in development of palatal rugae. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Gene Expression Patterns. 2019, 34, 119062. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.gep.2019.119062 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 2019 Elsevier B.V. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4725号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(歯)甲第449号 | |||||
