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Modulatory effects of repeated psychophysical stress on masseter muscle nociception in the nucleus raphe magnus of rats
http://hdl.handle.net/10191/00051741
http://hdl.handle.net/10191/00051741d0bbf30d-f30e-4252-a87a-8e873dc7e479
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.9 MB)
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要旨 (240.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-08-31 | |||||
| タイトル | ||||||
| タイトル | Modulatory effects of repeated psychophysical stress on masseter muscle nociception in the nucleus raphe magnus of rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pain | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nucleus raphe magnus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | repeated forced swim stress | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | masseter muscle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | serotonin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | rostral ventromedial medulla | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 情動ストレスは大縫線核(NRM)での咬筋侵害応答を増大させる | |||||
| 著者 |
Shimizu, Shiho
× Shimizu, Shiho |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177916 | |||||
| 姓名 | 清水, 志保 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Psychophysical stress could increase nociception in the orofacial region including the masseter muscle, and neural changes in the brain contribute to increases in masseter muscle nociception under psychophysical stress conditions. The nucleus raphe magnus (NRM) located in the brain stem serves crucial roles to regulate nociception as descending pain controls. However, it remains unclear if neural activities in the NRM could be affected under psychophysical stress conditions. This study conducted experiments to assess (1) whether neural activity, indicated by Fos expression in the NRM evoked by masseter muscle injury, is modulated by the repeated forced swim stress (FST); (2) whether the selective serotonin reuptake inhibitor, fluoxetine, administered daily after FST could affect the number of Fos-positive neurons in the NRM. Results revealed that repeated forced swim stress significantly increased the number of Fos-positive neurons in the NRM evoked by masseter muscle injury. Fluoxetine inhibited increases in the number of Fos-positive neurons in the NRM in FST, but not in sham rats. These findings indicated that FST could increase in nociceptive neural activities in the NRM evoked by masseter muscle injury, which could be due to changes in serotonergic mechanisms at least, in part. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Oral Science. 2020, 62(2), 231-235. | |||||
| 書誌情報 | p. 1-15 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.2334/josnusd.19-0320 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(歯学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4724号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(歯)甲第448号 | |||||
