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Loss of autophagy in chondrocytes causes severe growth retardation
http://hdl.handle.net/10191/00051713
http://hdl.handle.net/10191/00051713c2e5b805-20e0-4918-881b-f07098d4d993
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2020-07-08 | |||||
タイトル | ||||||
タイトル | Loss of autophagy in chondrocytes causes severe growth retardation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atg7 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | autophagy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cartilage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chondrogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glycogenolysis | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_46ec | |||||
タイプ | thesis | |||||
その他のタイトル | ||||||
その他のタイトル | 軟骨細胞におけるオートファジー欠損は重度の成長障害を引き起こす | |||||
著者 |
Horigome, Yoji
× Horigome, Yoji |
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著者別名 | ||||||
識別子 | 177875 | |||||
識別子Scheme | WEKO | |||||
姓名 | 堀米, 洋二 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Chondrogenesis is accompanied by not only cellular renovation, but also metabolic stress. Therefore, macroautophagy/autophagy is postulated to be involved in this process. Previous reports have shown that suppression of autophagy during chondrogenesis causes mild growth retardation. However, the role of autophagy in chondrocyte differentiation still largely remains unclear. Here, we show the important role of autophagy on chondrogenesis. The transition of mesenchymal cells to chondrocytes was severely impaired by ablation of Atg7, a gene essential for autophagy. Mice lacking Atg7 after the transition exhibited phenotypes severer than mutant mice in which Atg7 was removed before the transition. Atg7-deficient chondrocytes accumulated large numbers of glycogen granules, hardly proliferate and died specifically in the proliferative zone without any ER-stress signal. Our results suggest that the suppression of autophagy in prechondrogenic cells drives compensatory mechanism(s) that mitigate defective chondrogenesis, and that autophagy participates in glycogenolysis to supply glucose in avascular growth plates. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Autophagy. 2020, 16(3), 501-511. | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1080/15548627.2019.1628541 | |||||
権利 | ||||||
権利情報 | 【○!C】 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | |||||
著者版フラグ | ||||||
値 | ETD | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関名 | 新潟大学 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2019-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 13101甲第4632号 | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 新大院博(医)甲第892号 |