{"_buckets": {"deposit": "17e02928-8344-4e17-9b53-332d72be31a9"}, "_deposit": {"id": "33915", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "33915"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00033915", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "軟骨細胞におけるオートファジー欠損は重度の成長障害を引き起こす"}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2019-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Chondrogenesis is accompanied by not only cellular renovation, but also metabolic stress. Therefore, macroautophagy/autophagy is postulated to be involved in this process. Previous reports have shown that suppression of autophagy during chondrogenesis causes mild growth retardation. However, the role of autophagy in chondrocyte differentiation still largely remains unclear. Here, we show the important role of autophagy on chondrogenesis. The transition of mesenchymal cells to chondrocytes was severely impaired by ablation of Atg7, a gene essential for autophagy. Mice lacking Atg7 after the transition exhibited phenotypes severer than mutant mice in which Atg7 was removed before the transition. Atg7-deficient chondrocytes accumulated large numbers of glycogen granules, hardly proliferate and died specifically in the proliferative zone without any ER-stress signal. Our results suggest that the suppression of autophagy in prechondrogenic cells drives compensatory mechanism(s) that mitigate defective chondrogenesis, and that autophagy participates in glycogenolysis to supply glucose in avascular growth plates.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Autophagy. 2020, 16(3), 501-511.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)甲第892号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4632号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "177875", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "堀米, 洋二"}]}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1080/15548627.2019.1628541", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 2019 The Author(s). Published by Informa UK Limited, trading as Taylor \u0026 Francis Group."}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Horigome, Yoji"}], "nameIdentifiers": [{"nameIdentifier": "177874", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-07-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r1nmk892.pdf", "filesize": [{"value": "4.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4200000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/33915/files/r1nmk892.pdf"}, "version_id": "62beed59-8416-49b4-84d3-d3e1bd6ebf25"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-07-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r1nmk892_a.pdf", "filesize": [{"value": "639.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 639700.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/33915/files/r1nmk892_a.pdf"}, "version_id": "7d85d640-38c1-4596-af8c-2e741e9de27e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Atg7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autophagy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cartilage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "chondrogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glycogenolysis", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Loss of autophagy in chondrocytes causes severe growth retardation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Loss of autophagy in chondrocytes causes severe growth retardation"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/00051713", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-07-08"}, "publish_date": "2020-07-08", "publish_status": "0", "recid": "33915", "relation": {}, "relation_version_is_last": true, "title": ["Loss of autophagy in chondrocytes causes severe growth retardation"], "weko_shared_id": null}