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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Loss of autophagy in chondrocytes causes severe growth retardation

http://hdl.handle.net/10191/00051713
http://hdl.handle.net/10191/00051713
c2e5b805-20e0-4918-881b-f07098d4d993
名前 / ファイル ライセンス アクション
r1nmk892.pdf 本文 (4.2 MB)
r1nmk892_a.pdf 要旨 (639.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2020-07-08
タイトル
タイトル Loss of autophagy in chondrocytes causes severe growth retardation
言語
言語 eng
キーワード
主題Scheme Other
主題 Atg7
キーワード
主題Scheme Other
主題 autophagy
キーワード
主題Scheme Other
主題 cartilage
キーワード
主題Scheme Other
主題 chondrogenesis
キーワード
主題Scheme Other
主題 glycogenolysis
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 軟骨細胞におけるオートファジー欠損は重度の成長障害を引き起こす
著者 Horigome, Yoji

× Horigome, Yoji

WEKO 177874

Horigome, Yoji

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著者別名
識別子 177875
識別子Scheme WEKO
姓名 堀米, 洋二
抄録
内容記述タイプ Abstract
内容記述 Chondrogenesis is accompanied by not only cellular renovation, but also metabolic stress. Therefore, macroautophagy/autophagy is postulated to be involved in this process. Previous reports have shown that suppression of autophagy during chondrogenesis causes mild growth retardation. However, the role of autophagy in chondrocyte differentiation still largely remains unclear. Here, we show the important role of autophagy on chondrogenesis. The transition of mesenchymal cells to chondrocytes was severely impaired by ablation of Atg7, a gene essential for autophagy. Mice lacking Atg7 after the transition exhibited phenotypes severer than mutant mice in which Atg7 was removed before the transition. Atg7-deficient chondrocytes accumulated large numbers of glycogen granules, hardly proliferate and died specifically in the proliferative zone without any ER-stress signal. Our results suggest that the suppression of autophagy in prechondrogenic cells drives compensatory mechanism(s) that mitigate defective chondrogenesis, and that autophagy participates in glycogenolysis to supply glucose in avascular growth plates.
内容記述
内容記述タイプ Other
内容記述 Autophagy. 2020, 16(3), 501-511.
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1080/15548627.2019.1628541
権利
権利情報 【○!C】 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-09-20
学位授与番号
学位授与番号 13101甲第4632号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第892号
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