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The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias
http://hdl.handle.net/10191/00051709
http://hdl.handle.net/10191/000517095777d52c-9d26-40a9-923d-5ffc0fbb6664
| 名前 / ファイル | ライセンス | アクション |
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本文 (239.5 kB)
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要旨 (481.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-07-08 | |||||
| タイトル | ||||||
| タイトル | The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Arrhythmias | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Drugs | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Sudden death | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Electrical storm | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Heart diseases | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 難治性心室性不整脈に対するニフェカラント(Kチャネル遮断薬)・メキシレチン(Naチャネル遮断薬)の効果 | |||||
| 著者 |
Otuki, Sou
× Otuki, Sou |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 177868 | |||||
| 姓名 | 大槻, 総 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant, a pure potassium channel blocker, and mexiletine for electrical storm. Methods: This study included 44 patients with repetitive ventricular tachyarrhythmias who received stepwise therapy with nifekalant and mexiletine for electrical storm. Nifekalant was initially administered, and mexiletine was subsequently added if nifekalant failed to control ventricular tachyarrhythmias. Results: Nifekalant completely suppressed recurrences of ventricular arrhythmias in 28 patients (64%), including 6 patients in whom oral amiodarone failed to control arrhythmias. In 9 of 16 patients in whom nifekalant was partially effective but failed to suppress ventricular arrhythmias, mexiletine was added. The addition of mexiletine prevented recurrences of ventricular tachyarrhythmias in 5 of these 9 patients (56%). There was no death associated with electrical storm. In total, the stepwise treatment with nifekalant and mexiletine was effective in preventing ventricular tachyarrhythmias in 33 of 44 patients (75%). There was no difference in cycle length of the ventricular tachycardia, QRS interval, QT interval, or left ventricular ejection fraction between patients who responded to antiarrhythmic drugs and those who did not. During follow-up, 8 patients had repetitive ventricular tachyarrhythmia recurrences, and the stepwise treatment was effective in 6 of these 8 patients (75%). Conclusions: The stepwise treatment with nifekalant and mexiletine was highly effective in the suppression of electrical storm. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Electrocardiology. 2017, 50(3), 277-281. | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.jelectrocard.2016.09.005 | |||||
| 権利 | ||||||
| 権利情報 | 【○!C】 2016 Published by Elsevier Inc. | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4628号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博(医)甲第888号 | |||||
