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MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females : a cross-sectional study
http://hdl.handle.net/10191/51260
http://hdl.handle.net/10191/51260fd335187-d2a0-4a8d-b297-85a341dde000
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本文 (550.2 kB)
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要旨 (272.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2019-07-08 | |||||
| タイトル | ||||||
| タイトル | MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females : a cross-sectional study | |||||
| タイトル | ||||||
| タイトル | MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females : a cross-sectional study | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 閉経後日本人女性におけるMAEA rs6815464多型と歯周炎 : 横断研究 | |||||
| 著者 |
Che, Yulan
× Che, Yulan |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 175234 | |||||
| 姓名 | 車, 玉蘭 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Macrophage erythroblast attacher (MAEA) is a membrane protein that regulates the development of mature macrophages by mediating attachment with erythroblasts. A polymorphism rs6815464 (C/G) in MAEA gene was reported to be associated with type II diabetes. Along with diabetes, osteoporosis shows an increased prevalence in postmenopausal females, and both diseases have been reported to be associated with periodontitis. Therefore, we explored the relevance of the MAEA polymorphism to periodontitis, bone mineral density (BMD) and haemoglobin A1c (HbA1c). Design: This was a cross-sectional study with the final sample comprised of 344 postmenopausal Japanese females. Probing pocket depth (PPD) and clinical attachment level (CAL) were measured. Genotype was determined by TaqMan assay. Blood biochemical parameters and BMD of the lumbar spine were evaluated. Results: No differences were found in age, body mass index, HbA1c, BMD, number of teeth, bone metabolism parameters between the genotypes. Mean CAL and percentage of sites with PPD or CAL ≥5mm were higher in the G-allele carriers than in the non-carriers. Multiple logistic regression analyses revealed that G-allele carriage was associated with severe periodontitis (odds ratio = 3.68, 95% CI =1.35-10.05). Conclusion: Our results suggested that the MAEA gene polymorphism was independently associated with severe periodontitis. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（歯学）. 報告番号: 甲第4573号. 学位記番号: 新大院博（歯）甲第422号. 学位授与年月日: 平成31年3月25日 | |||||
| 書誌情報 | 発行日 2019-03-25 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2019-03-25 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4573号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（歯）甲第422号 | |||||
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Cite as
Che, Yulan, 2019, MAEA rs6815464 polymorphism and periodontitis in postmenopausal Japanese females : a cross-sectional study: 新潟大学.
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