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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Prognostic impact of the tumor immune microenvironment in synovial sarcoma

http://hdl.handle.net/10191/51304
http://hdl.handle.net/10191/51304
6bcb0025-9f03-4e44-9e76-aea630b5bffb
名前 / ファイル ライセンス アクション
h30nmk878.pdf 本文 (1.5 MB)
h30nmk878_a.pdf 要旨 (694.8 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-07-09
タイトル
タイトル Prognostic impact of the tumor immune microenvironment in synovial sarcoma
タイトル
言語 en
タイトル Prognostic impact of the tumor immune microenvironment in synovial sarcoma
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 滑膜肉腫における腫瘍免疫環境と予後との関連
著者 Oike, Naoki

× Oike, Naoki

WEKO 175200

Oike, Naoki

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著者別名
識別子 175201
識別子Scheme WEKO
姓名 大池, 直樹
抄録
内容記述タイプ Abstract
内容記述 The association between the immune status within the tumor microenvironment and prognosis in synovial sarcoma is not well understood. We aimed to investigate the tumor immune microenvironment and analyze its prognostic impact for patients with synovial sarcoma. A total of 36 primary patients who were treated in our institution were retrospectively evaluated. Infiltration of lymphocytes (CD4+, CD8+, and FOXP3+), CD163+ macrophages, and expression of human leukocyte antigen (HLA) class I and programmed death ligand 1 (PD‐L1) were evaluated by immunohistochemistry. Moreover, we investigated PD‐L1 and programmed death ligand 2 (PD‐L2) mRNA expression in 19 of the 36 cases, using real‐time PCR. The Kaplan‐Meier method was used to estimate overall survival and progression‐free survival. Infiltration of lymphocytes and macrophages varied among the patients. Furthermore, the expression of HLA class I was negative or downregulated in 11 specimens. No PD‐L1 expression was observed using immunohistochemistry. Moreover, although PD‐L1 mRNA expression was observed in 18 of 19 specimens, the expression level was low. A higher infiltration of CD8+ or FOXP3+ lymphocytes in patients was associated with a favorable overall survival. In addition, a higher infiltration of CD163+ macrophages indicated a significantly worse overall and progression‐free survival. Infiltration of CD4+ lymphocytes, HLA class I, PD‐L1, and PD‐L2 expression were not associated with patient prognosis. This represents the first report investigating the tumor immune microenvironment as a prognostic factor in synovial sarcoma, indicating that CD163+ macrophages are associated with tumor progression. Our results underscore the clinical significance of the tumor immune microenvironment in synovial sarcoma.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4556号. 学位記番号: 新大院博(医)甲第878号. 学位授与年月日: 平成31年3月25日
書誌情報 発行日 2019-03-25
出版者
出版者 新潟大学
権利
権利情報 【○!C】2018 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-03-25
学位授与番号
学位授与番号 13101甲第4556号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第878号
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