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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Effects of olanzapine on resting heart rate in Japanese patients with schizophrenia

http://hdl.handle.net/10191/51319
http://hdl.handle.net/10191/51319
9f7bb1eb-04ac-4d30-8e30-675aac96e250
名前 / ファイル ライセンス アクション
h30nmk871.pdf 本文 (984.9 kB)
h30nmk871_a.pdf 要旨 (570.3 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2019-07-09
タイトル
タイトル Effects of olanzapine on resting heart rate in Japanese patients with schizophrenia
タイトル
言語 en
タイトル Effects of olanzapine on resting heart rate in Japanese patients with schizophrenia
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 日本人統合失調症患者の安静時心拍数にオランザピンが与える影響
著者 Tajiri, Misuzu

× Tajiri, Misuzu

WEKO 175186

Tajiri, Misuzu

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著者別名
識別子 175187
識別子Scheme WEKO
姓名 田尻, 美寿々
抄録
内容記述タイプ Abstract
内容記述 It has long been known that antipsychotic drugs (ATP) causes tachycardia, however details such as the differences between ATP are not well known. In recent years, the relationship between the rise in resting heart rate (RHR) and the increased risk of death in the general population has been garnering attention. In this study, we examined the difference in action on RHR between olanzapine (OLZ) and aripiprazole (ARP). The changes in the RHR on switching from OLZ to ARP and on increasing from the starting OLZ dose to the final one were evaluated in 19 outpatients (Study 1) and in 29 outpatients with schizophrenia (Study 2), respectively. To analyze the RHR, electrocardiographic measurements were obtained. At the same day, the Brief Psychiatric Rating Scale (BPRS) was evaluated, and fasting blood samples were drawn after an overnight fast of at least 8 h to examine electrolytes. Both Study 1 and 2 were conducted with the approval of the Gene Ethics Committee of Niigata University Graduate School of Medical and Dental Sciences, and the patients were treated at the outpatient psychiatric clinic at Niigata University Medical and Dental Hospital. All patients had been diagnosed with schizophrenia based on the DSM-IV-TR. In the Study 1, OLZ of 14.6 ± 9.2mg (mean ± standard deviation) was switched to ARP of 20.8 ± 8.1mg. Significant decreases were observed in the mean RHR after the switch to ARP (73.7 ± 9.7 vs 65.8 ± 10.9 beats/min, p = 0.008). In the Study 2, the starting OLZ dose was 7.2 ± 3.2mg and the increasing OLZ dose was 18.3 ± 7.4mg. Significant increases were observed in the mean RHR after increasing OLZ (69.7 ± 14.0 vs 75.6 ± 14.3 beats/min, p = 0.004). In this study, it was shown that OLZ has a stronger RHR enhancing effect compared to ARP and its effects are dose-dependent. If the increase in RHR increases the mortality rate of patients with schizophrenia, it may be necessary to further investigate the differences between ATP in terms of the effect on RHR of second-generation antipsychotics with a strong anticholinergic action or phenothiazine antipsychotics.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4549号. 学位記番号: 新大院博(医)甲第871号. 学位授与年月日: 平成31年3月25日
書誌情報 発行日 2019-03-25
出版者
出版者 新潟大学
権利
権利情報 【○!C】2018 Tajiri et al.
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2019-03-25
学位授与番号
学位授与番号 13101甲第4549号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第871号
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