{"_buckets": {"deposit": "b7607afe-58f3-4126-b1c7-8f45dd674516"}, "_deposit": {"id": "32024", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "32024"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00032024"}, "item_6_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u30a4\u30f3\u30c9\u30ad\u30b7\u30eb\u786b\u9178\u306f\u3001\u30a2\u30ea\u30eb\u30cf\u30a4\u30c9\u30ed\u30ab\u30fc\u30dc\u30f3\u53d7\u5bb9\u4f53/NF-_K/MAPK\u7d4c\u8def\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066IL-1\u03b2\u306e\u767a\u73fe\u3092\u4ea2\u9032\u3055\u305b\u308b\u304c\u3001NLRP3\u30a4\u30f3\u30d5\u30e9\u30de\u30bd\u30fc\u30e0\u3092\u6d3b\u6027\u5316\u3057\u306a\u3044\u3002"}]}, "item_6_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2018-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One of the hallmarks of kidney disease-related cardiovascular disease is intravascular macrophage inflammation, but the mechanism of the reaction with these toxins is not completely understood. Macrophages differentiated from THP-1 cells were exposed to indoxyl sulfate (IS), a representative uremic toxin, and changes in inflammatory cytokine production and intracellular signaling molecules including interleukin (IL)-1, aryl hydrocarbon receptor (AhR), nuclear factor (NF)-_K, and mitogen-activated protein kinase (MAPK) cascades as well as the NLRP3 inflammasome were quantified by real-time PCR, Western blot analysis, and enzyme-linked immunosorbent assay. IS induced macrophage pro-IL-1\u03b2 mRNA expression, although mature IL-1 was only slightly increased. IS increased AhR and the AhR-related mRNA expression; this change was suppressed by administration of proteasome inhibitor. IS promoted phosphorylation of NF-_KB p65 and MAPK enzymes; the reaction and IL-1 expression were inhibited by BAY11-7082, an inhibitor of NF-_KB. In contrast, IS decreased NLRP3 and did not change ASC, pro-caspase 1, or caspase-1 activation. IS-inducing inflammation in macrophages results from accelerating AhR-NF-_KB/MAPK cascades, but the NLRP3 inflammasome was not activated. These reactions may restrict mature IL-1\u03b2 production, which may explain sustained chronic inflammation in CKD patients.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u5b66\u4f4d\u306e\u7a2e\u985e: \u535a\u58eb\uff08\u533b\u5b66\uff09. \u5831\u544a\u756a\u53f7: \u7532\u7b2c4498\u53f7. \u5b66\u4f4d\u8a18\u756a\u53f7: \u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c835\u53f7. \u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5: \u5e73\u621030\u5e749\u670820\u65e5", "subitem_description_type": "Other"}, {"subitem_description": "Toxins. 2018, 10, 124.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u9662\u535a\uff08\u533b\uff09\u7532\u7b2c835\u53f7", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101\u7532\u7b2c4498\u53f7"}]}, "item_6_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "175082", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u82e5\u677e, \u62d3\u4e5f"}]}]}, "item_6_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.3390/toxins10030124", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Wakamatsu, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "175081", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30nmk835.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "\u672c\u6587", "url": "https://niigata-u.repo.nii.ac.jp/record/32024/files/h30nmk835.pdf"}, "version_id": "bd5c0165-b802-4e2f-8153-01d2470f5319"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30nmk835_a.pdf", "filesize": [{"value": "539.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 539800.0, "url": {"label": "\u8981\u65e8", "url": "https://niigata-u.repo.nii.ac.jp/record/32024/files/h30nmk835_a.pdf"}, "version_id": "d6ac81b5-0d15-4a0c-82d0-d747c204d6f4"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "uremic toxins", "subitem_subject_scheme": "Other"}, {"subitem_subject": "indoxyl sulfate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "aryl hydrocarbon receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nuclear factor-_KB", "subitem_subject_scheme": "Other"}, {"subitem_subject": "inflammasome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atherosclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cardiovascular disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Indoxyl Sulfate Promotes Macrophage IL-1\u03b2 Production by Activating Aryl Hydrocarbon Receptor/NF-_K/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Indoxyl Sulfate Promotes Macrophage IL-1\u03b2 Production by Activating Aryl Hydrocarbon Receptor/NF-_K/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated"}, {"subitem_title": "Indoxyl Sulfate Promotes Macrophage IL-1\u03b2 Production by Activating Aryl Hydrocarbon Receptor/NF-_K/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/50778", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-11-29"}, "publish_date": "2018-11-29", "publish_status": "0", "recid": "32024", "relation": {}, "relation_version_is_last": true, "title": ["Indoxyl Sulfate Promotes Macrophage IL-1\u03b2 Production by Activating Aryl Hydrocarbon Receptor/NF-_K/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated"], "weko_shared_id": 2}