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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice

http://hdl.handle.net/10191/50781
http://hdl.handle.net/10191/50781
bfb44772-3006-4f23-8bbb-9aa4b4b8594c
名前 / ファイル ライセンス アクション
h30nmk834.pdf 本文 (6.1 MB)
h30nmk834_a.pdf 要旨 (448.7 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-11-29
タイトル
タイトル Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice
タイトル
言語 en
タイトル Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル クラスター型プロトカドヘリンαの分子多様性に依存するマウス感覚統合機能と短期記憶
著者 Yamagishi, Tatsuya

× Yamagishi, Tatsuya

WEKO 175079

Yamagishi, Tatsuya

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著者別名
識別子 175080
識別子Scheme WEKO
姓名 山岸, 達矢
抄録
内容記述タイプ Abstract
内容記述 Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by hemophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4497号. 学位記番号: 新大院博(医)甲第834号. 学位授与年月日: 平成30年9月20日
内容記述
内容記述タイプ Other
内容記述 Scientific Reports. 2018, 8, 9616.
書誌情報 発行日 2018-09-20
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1038/s41598-018-28034-4
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-09-20
学位授与番号
学位授与番号 13101甲第4497号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第834号
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