{"_buckets": {"deposit": "82245b3f-515e-4287-89b1-cdd9c9868e44"}, "_deposit": {"id": "32023", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "32023"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00032023", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "クラスター型プロトカドヘリンαの分子多様性に依存するマウス感覚統合機能と短期記憶"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-09-20", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-09-20"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by hemophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士（医学）. 報告番号: 甲第4497号. 学位記番号: 新大院博（医）甲第834号. 学位授与年月日: 平成30年9月20日", "subitem_description_type": "Other"}, {"subitem_description": "Scientific Reports. 2018, 8, 9616.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（医）甲第834号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4497号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "175080", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "山岸, 達矢"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1038/s41598-018-28034-4", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamagishi, Tatsuya"}], "nameIdentifiers": [{"nameIdentifier": "175079", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h30nmk834.pdf", "filesize": [{"value": "6.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 6100000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/32023/files/h30nmk834.pdf"}, "version_id": "2d982b09-b506-41b2-af36-2d207e6cfb3f"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-09-10"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h30nmk834_a.pdf", "filesize": [{"value": "448.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 448700.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/32023/files/h30nmk834_a.pdf"}, "version_id": "939fc4ba-1de4-4f6e-8025-9688f1799c84"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice"}, {"subitem_title": "Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/50781", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-11-29"}, "publish_date": "2018-11-29", "publish_status": "0", "recid": "32023", "relation": {}, "relation_version_is_last": true, "title": ["Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice"], "weko_shared_id": 2}