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Different distribution of mucosal-associated invariant T cells within the human cecum and colon
http://hdl.handle.net/10191/50777
http://hdl.handle.net/10191/50777601fd638-cfa0-4862-b6cf-294681f6cd23
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本文 (722.4 kB)
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要旨 (522.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-11-29 | |||||
| タイトル | ||||||
| タイトル | Different distribution of mucosal-associated invariant T cells within the human cecum and colon | |||||
| タイトル | ||||||
| タイトル | Different distribution of mucosal-associated invariant T cells within the human cecum and colon | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 盲腸と結腸の粘膜におけるMAIT細胞に関する検討 | |||||
| 著者 |
Hama, Isamu
× Hama, Isamu |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 175066 | |||||
| 姓名 | 濱, 勇 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mucosal-associated invariant T (MAIT) cells are innate-like T cells that are involved in anti-bacterial immunity. MAIT cells are found in the intestine, but their role and distribution within the large intestine have not been fully elucidated. Therefore, we investigated the distribution of MAIT cells within the cecum and colon. Surgically resected tissues of the cecum and colon were obtained from 4 patients with cecal appendix cancer and 8 patients with colorectal cancer, respectively. Lymphocytes were isolated from the intestinal epithelium (intraepithelial lymphocytes, IELs) and the underlying lamina propria (lamina propria lymphocytes, LPLs), and then, MAIT cells were analyzed by flow cytometry. Compared with the colon, the cecum showed a significantly increased frequency of MAIT cells among IELs (P<0.01). CD69 expression on MAIT cells was significantly increased in the cecum and colon compared with that in the blood, and the frequency of natural killer group 2, member A^+ cells among MAIT cells was significantly increased in the cecum. These results suggest that the distribution of MAIT cells was different between the cecum and colon and that MAIT cells were more likely to be activated, especially in the intestinal epithelium of the cecum than in the colon and blood. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 甲第4490号. 学位記番号: 新大院博（医）甲第827号. 学位授与年月日: 平成30年9月20日 | |||||
| 書誌情報 | p. 1-29, 発行日 2018-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4490号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（医）甲第827号 | |||||
