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Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes
http://hdl.handle.net/10191/50775
http://hdl.handle.net/10191/507758b2173ae-968f-4abf-9eec-6e6248aebe9c
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本文 (255.9 kB)
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要旨 (321.3 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-11-29 | |||||
| タイトル | ||||||
| タイトル | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes | |||||
| タイトル | ||||||
| タイトル | Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bronchial provocation test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fraction of exhaled NO | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IgE | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Inhaled corticosteroid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pulmonary function testing | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 日本人アスリート喘息における吸入ステロイドの効果 | |||||
| 著者 |
Hoshino, Yoshifumi
× Hoshino, Yoshifumi |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 175064 | |||||
| 姓名 | 星野, 芳史 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatment in the athlete population in clinical practice. In this study, we focused on the clinical efficacy of inhaled corticosteroid (ICS) for asthma in a Japanese athlete population. Methods: The study subjects included athletes who visited the Niigata Institute for Health and Sports Medicine, Niigata, Japan for athletic tests and who were diagnosed with asthma on the basis of respiratory symptoms and positive results in a bronchodilator or bronchial provocation test such as exercise, hypertonic saline, or methacholine provocation. The athletes received ICS alone for at least 3 months, and the clinical background, sports type, and treatment efficacy were analyzed. Results: The study population comprised 80 athletes (59 men and 21 women) with a median age of 16.0 years. Regarding sports type, 28 athletes engaged in winter sports (35%), 22 in endurance sports (27.5%), and 25 in indoor sports (31.3%). Although ICS is the primary treatment in athlete asthma, 16.3% of the athletes showed an unsatisfactory response to treatment according to the Global Evaluation of Treatment Effectiveness (GETE). These subjects were characterized by a decreased response to methacholine and lower values for FEV_1/FVC and type 2 helper T cell (Th2)-associated biomarkers relative to responsive athletes. In multivariate analysis, FEV_1/FVC and the logarithm to the base 10 of the IgE level were independently associated with the ICS response. Conclusions: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（医学）. 報告番号: 乙第2228号. 学位記番号: 新大博（医）乙第1800号. 学位授与年月日: 平成30年9月20日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Allergology International. 2015, 64(2), 145-149. | |||||
| 書誌情報 | 発行日 2018-09-20 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/j.alit.2014.10.004 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（医学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-09-20 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101乙第2228号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大博（医）乙第1800号 | |||||
