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We addressed whether aurora kinase inhibitor effectively induces the cell death in HCC cells. Methods: Hepatoma HepG2 cells were treated with aurora kinase inhibitor AZD1152 with or without sorafenib for 24-72 hours. Cell signaling was analyzed by Western blotting, cell apoptosis was calculated by annexin V and trypan blue, and cell proliferation was examined by MTT assay. Results: Trypan blue and annexin V assays showed that AZD1152 alone rarely induced cell apoptosis. AZD1152 treatment resulted in the increased level of phosphorylated ERK. Combination treatment with AZD1152 and chemical inhibitor of ERK or sorafenib effectively increased the cell apoptosis in HepG2 cells (p \u003c 0.01). Conclusion: ERK is a critical mediator of drug resistance of AZD1152 in hepatoma cells. Combination treatment with sorafenib and AZD1152 might be an effective tool for treating HCC.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "164375", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Osawa, Mami"}]}, {"nameIdentifiers": [{"nameIdentifier": "164376", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Matsuda, Yasunobu"}]}, {"nameIdentifiers": [{"nameIdentifier": "164377", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Wakai, Toshifumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "164378", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hirose, Yuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "164379", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nagahashi, Masayuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "164380", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sakata, Jun"}]}, {"nameIdentifiers": 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