{"_buckets": {"deposit": "04970a15-fd50-4157-addc-890561b29690"}, "_deposit": {"id": "28498", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28498"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028498"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u767a\u751f\u521d\u671f\u306e\u30de\u30a6\u30b9\u306e\u5375\u5b50\u3068\u521d\u671f\u80da\u306b\u304a\u3051\u308b\u30d7\u30ed\u30b8\u30a7\u30b9\u30bf\u30b8\u30a7\u30f3\u5408\u6210\u306b\u95a2\u3059\u308b\u7d44\u7e54\u5316\u5b66\u7684\u7814\u7a76"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "97", "bibliographicPageStart": "91", "bibliographicVolumeNumber": "55", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a"}, {"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The activities of \u25b3^5-3\u03b2-hydroxysteroid dehydrogenase (\u25b3^5-3\u03b2-HSD) (pregnenolone and 17\u03b1-hydroxypregnenolone as the substrates), 20\u03b1-HSD (20\u03b1-hydroxyprogesterone as the substrate) and 20\u03b2-HSD (17\u03b1-hydroxyprogesterone and 20\u03b2-hydroxyprogesterone as the substrates) were histochemically demonstrated in mouse eggs and embryos, and the progestagen production in those during the early development was examined. In unfertilized mouse eggs, the activities of such HSDs were observed in 88 to 98% of those. The percentages of embryos showing the activities of such HSDs did not change during the early development. It was also histochemically confirmed that the activity of \u25b3^5-3\u03b2 HSD with DHA as the substrate, which is involved in steroid biosynthesis, was observed in 86 to 100% of the eggs and embryos from the un fertilized to blastocyst stages. From the present findings, it was suggested that the progestagens such as progesterone, 17\u03b1-hydroxyprogesterone, 17\u03b1,20\u03b2-dihydroxyprogesterone, 20\u03b1-hydroxyprogesterone and 20\u03b2-hydroxyprogesterone are constantly synthesized in mouse eggs and embryos during the early development.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u30de\u30a6\u30b9\u306e\u672a\u53d7\u7cbe\u5375\u5b50\u304a\u3088\u3073\u524d\u6838\u671f\u304b\u3089\u80da\u76e4\u62b1\u671f\u307e\u3067\u306e\u521d\u671f\u80da\u306b\u3064\u3044\u3066\u3001\u25b3^5-3\u03b2-HSD(\u57fa\u8cea\u3068\u3057\u3066pregnenolone\u304a\u3088\u307317\u03b1-hydroxypregnenolone\u3092\u4f7f\u7528)\u3001 20\u03b1-HSD (20\u03b1-hydroxyprogesterone)\u304a\u3088\u307320\u03b2-HSD (17\u03b1-hydroxyprogesterone\u3001 20\u03b2-hydroxyprogesterone)\u306e\u6d3b\u6027\u3092\u7d44\u7e54\u5316\u5b66\u7684\u306b\u691c\u51fa\u3057\u3001\u30d7\u30ed\u30b8\u30a7\u30b9\u30bf\u30b8\u30a7\u30f3\u5408\u6210\u80fd\u3092\u691c\u8098\u3057\u305f\u3002\u672a\u53d7\u7cbe\u671f\u306e\u5375\u5b50\u306b\u304a\u3044\u3066\u3001\u3053\u308c\u3089HSD\u306e\u6d3b\u6027\u306f88\u306a\u3044\u305798%\u306e\u3082\u306e\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002\u307e\u305f\u3001\u524d\u6838\u671f\u304b\u3089\u80da\u76e4\u62b1\u671f\u307e\u3067\u306e\u521d\u671f\u80da\u306b\u304a\u3044\u3066\u3082\u3001 83%\u4ee5\u4e0a\u3067\u3053\u308c\u3089\u306eHSD\u6d3b\u6027\u304c\u691c\u51fa\u3055\u308c\u305f\u3002\u4e00\u65b9\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u751f\u5408\u6210\u306e\u6307\u6a19\u3068\u306a\u308b\u25b3^5-3\u03b2-HSD (DHA)\u306e\u6d3b\u6027\u306f\u3001 86%\u4ee5\u4e0a\u306e\u5375\u5b50\u3068\u521d\u671f\u80da\u306b\u5e38\u306b\u89b3\u5bdf\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u767a\u751f\u521d\u671f\u306e\u30de\u30a6\u30b9\u306e\u5375\u5b50\u3068\u80da\u306f\u3001\u5e38\u306bprogesterone\u3001 17\u03b1-hydroxyprogesterone. 17\u03b1,20\u03b2-hydroxyprogesterone\u3001 20\u03b1-hydroxyprogesterone\u304a\u3088\u307320\u03b2-hydroxyprogesterone\u306e\u5408\u6210\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u30d7\u30ed\u30b8\u30a7\u30b9\u30bf\u30b8\u30a7\u30f3\u306e\u5408\u6210\u80fd\u306f\u3001\u80da\u306e\u521d\u671f\u767a\u751f\u306b\u4f34\u3063\u3066\u5909\u5316\u3057\u306a\u3044\u3053\u3068\u304c\u8003\u3048\u3089\u308c\u305f\u3002", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "163935", "nameIdentifierScheme": "WEKO"}], "names": [{"name": 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"nameIdentifiers": [{"nameIdentifier": "163933", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawakami, Shin-ya"}], "nameIdentifiers": [{"nameIdentifier": "163934", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "55_2_91-97.pdf", "filesize": [{"value": "490.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 490100.0, "url": {"label": "55_2_91-97.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28498/files/55_2_91-97.pdf"}, "version_id": "4a2f487a-bd47-4f50-b10b-896debd98468"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", 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