{"_buckets": {"deposit": "6815e958-78c8-4964-add2-410f9ee074bc"}, "_deposit": {"id": "28372", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28372"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028372", "sets": ["456", "1597"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "オバルブミン感作したBALB/c マウスに対するγ- アミノ酪酸（GABA）の血清IgE レベル抑制作用"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "123", "bibliographicPageStart": "117", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "新潟大学農学部研究報告"}, {"bibliographic_title": "新潟大学農学部研究報告", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "γ-aminobutyric acid (GABA) is a kind of amino acid and has been received much attention for their biological activities. In the present study, we examined the influence of GABA on immunomodulatory activities and serum IgE levels, employing ovalbumin (OVA)-immunized BALB/c mice. In cytokine production assay in vitro, GABA showed increased IFN-γ production concomitant with decreased IL-4 production by splenocytes from OVA-immunized BALB/c mice. When administrated orally, GABA was effective for decreasing both total and OVA-specific IgE levels in serum. In addition, these decreased IgE levels by administrated GABA were paralleled with increased IFN-γ production and decreased IL-4 production in splenocytes ex vivo. It seems that GABA can potentially suppress Th2 responses including IL-4 production via promoting Th1-skewed response in vivo, leading to down-regulation of IgE synthesis. These results suggest that GABA might be useful for preventing IgE-mediated allergic diseases.", "subitem_description_type": "Abstract"}, {"subitem_description": "γ-アミノ酪酸（GABA）は，食品に含まれる機能性成分として注目されている。本研究では，オバルブミン（OVA）感作したBALB/cマウスに対するGABAの免疫制御活性について調べ，経口投与による血清IgEレベルの抑制作用について検討した。in vitro培養試験において，GABAはマウス脾細胞のインターフェロン-γ（IFN-γ）の産生を促進すると同時にインターロイキン-4（IL-4）の産生を抑制した。GABAを経口投与した結果，OVA感作BALB/cマウスにおける総IgE及びOVA特異的IgEの血清レベルが有意に低下した。さらに，ex vivo培養試験において，GABAを経口投与したマウスの脾細胞ではOVA誘導性のIFN-γ産生促進とIL-4産生抑制が認められた。GABAは，Th1の誘導を介してIL-4産生を始めとしたTh2応答を抑制し，IgE産生を抑制する可能性がある。以上の結果から，GABAはIgEが関与するアレルギー疾患の予防に有用であることが示唆される。", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "163214", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "堀, あゆみ"}]}, {"nameIdentifiers": [{"nameIdentifier": "163215", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "原, 崇"}]}, {"nameIdentifiers": [{"nameIdentifier": "163216", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "佐藤, 可奈"}]}, {"nameIdentifiers": [{"nameIdentifier": "163217", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "城, 斗志夫"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学農学部"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00183393", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03858634", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hori, Ayumi"}], "nameIdentifiers": [{"nameIdentifier": "163210", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "163211", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saito, Kana"}], "nameIdentifiers": [{"nameIdentifier": "163212", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Joh, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "163213", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "62(2)_117-123.pdf", "filesize": [{"value": "868.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 868200.0, "url": {"label": "62(2)_117-123.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28372/files/62(2)_117-123.pdf"}, "version_id": "6172d5ed-363b-4bba-9fed-76c903b0c8ba"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "γ-aminobutyric acid (GABA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-γ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "γ-アミノ酪酸（GABA）", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ヒスタミン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-γ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice"}, {"subitem_title": "Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1597"], "permalink_uri": "http://hdl.handle.net/10191/13103", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-07-14"}, "publish_date": "2010-07-14", "publish_status": "0", "recid": "28372", "relation": {}, "relation_version_is_last": true, "title": ["Influence of γ-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice"], 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