{"_buckets": {"deposit": "6815e958-78c8-4964-add2-410f9ee074bc"}, "_deposit": {"id": "28372", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28372"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028372"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "\u30aa\u30d0\u30eb\u30d6\u30df\u30f3\u611f\u4f5c\u3057\u305fBALB/c \u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308b\u03b3- \u30a2\u30df\u30ce\u916a\u9178\uff08GABA\uff09\u306e\u8840\u6e05IgE \u30ec\u30d9\u30eb\u6291\u5236\u4f5c\u7528"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2010-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "123", "bibliographicPageStart": "117", "bibliographicVolumeNumber": "62", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a"}, {"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "\u03b3-aminobutyric acid (GABA) is a kind of amino acid and has been received much attention for their biological activities. In the present study, we examined the influence of GABA on immunomodulatory activities and serum IgE levels, employing ovalbumin (OVA)-immunized BALB/c mice. In cytokine production assay in vitro, GABA showed increased IFN-\u03b3 production concomitant with decreased IL-4 production by splenocytes from OVA-immunized BALB/c mice. When administrated orally, GABA was effective for decreasing both total and OVA-specific IgE levels in serum. In addition, these decreased IgE levels by administrated GABA were paralleled with increased IFN-\u03b3 production and decreased IL-4 production in splenocytes ex vivo. It seems that GABA can potentially suppress Th2 responses including IL-4 production via promoting Th1-skewed response in vivo, leading to down-regulation of IgE synthesis. These results suggest that GABA might be useful for preventing IgE-mediated allergic diseases.", "subitem_description_type": "Abstract"}, {"subitem_description": "\u03b3-\u30a2\u30df\u30ce\u916a\u9178\uff08GABA\uff09\u306f\uff0c\u98df\u54c1\u306b\u542b\u307e\u308c\u308b\u6a5f\u80fd\u6027\u6210\u5206\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\uff0c\u30aa\u30d0\u30eb\u30d6\u30df\u30f3\uff08OVA\uff09\u611f\u4f5c\u3057\u305fBALB/c\u30de\u30a6\u30b9\u306b\u5bfe\u3059\u308bGABA\u306e\u514d\u75ab\u5236\u5fa1\u6d3b\u6027\u306b\u3064\u3044\u3066\u8abf\u3079\uff0c\u7d4c\u53e3\u6295\u4e0e\u306b\u3088\u308b\u8840\u6e05IgE\u30ec\u30d9\u30eb\u306e\u6291\u5236\u4f5c\u7528\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002in 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d2\u30b9\u30bf\u30df\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IL-4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IFN-\u03b3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Influence of \u03b3-aminobutyric acid (GABA) on IgE Production in Ovalbumin-immunized BALB/c Mice", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Influence of \u03b3-aminobutyric acid (GABA) on IgE Production in 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