{"_buckets": {"deposit": "411aee14-cdfa-4557-b8dd-39235d38c9fa"}, "_deposit": {"id": "28305", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28305"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028305", "sets": ["456", "1591"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Lactobacillus paracasei K71投与によるオボアルブミン感作したBALB/cマウスにおけるTh1細胞増加とTh2細胞減少"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "155", "bibliographicPageStart": "149", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "新潟大学農学部研究報告"}, {"bibliographic_title": "新潟大学農学部研究報告", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Lactobacillus paracasei K71 (L. paracasei K71) with stimulatory activity for interleukin-12 (IL-12) production has been isolated from Sakekasu (sake lees), a Japanese traditional fermented food coproduced during sake brewing. Oral administration of L. paracasei K71 significantly reduced serum immunoglobulin (Ig) E level in ovalbumin (OVA)-immunized BALB/c mice with type 2 helper T (Th2) polarization. In the present study, we examined the influence of L. paracasei K71 on Th1/Th2 cells population in spleen, employing OVA-immunized BALB/c mice. Orally administration of L. paracasei K71 resulted in an increase of CD4^+ T cells expressing CXCR3 (CD183) and a decrease of CD4^+ T cells expressing CCR4 (CD194) in splenocytes, in parallel with a reduction of total and OVA-specific IgE levels in serum. Since Th1 cells and Th2 cells preferentially express CXCR3 and CCR4 respectively, it seems that L. paracasei K71 can potentially induce Th1 cells and reduce Th2 cells in vivo, leading to down-regulation of IgE synthesis. The splenocytes from L. paracasei K71-administrated mice also showed lower IgE production level than those from control mice. These results suggest that L. paracasei K71 might be useful for improving Th2-dependent allergic diseases.", "subitem_description_type": "Abstract"}, {"subitem_description": "Lactobacillus paracasei K71 (K71株) は、IL-12産生促進作用を有する乳酸菌として日本酒の酒粕より分離された。Th2優位の状態にあるBALB/c マウスにオボアルブミン感作し、このマウスにK71株を経口投与すると、血中IgE レベル亢進を顕著に抑制した。本研究では、OVA 感作したBALB/c マウスを用い、脾臓におけるTh1/ Th2バランスに及ぼすK71株の影響について検討した。K71株を経口投与すると、血中の総IgE およびOVA 特異的IgE レベル亢進を抑制すると同時に、脾臓におけるCXCR3 (CD183) 陽性CD4^+T 細胞の増加とCCR4 (CD194) 陽性CD4^+T 細胞の減少が確認された。K71株投与群マウス脾臓細胞は、対象群マウス脾臓細胞よりIgE 産生能が低下していた。Th1およびTh2細胞はそれぞれCXCR3とCCR4を特徴的に発現することから、K71株は生体内でTh1細胞の増加とTh2細胞の減少を促し、IgE 産生の抑制に繋がることが伺える。以上の結果は、Th2型免疫応答が関与するアレルギー疾患の改善にK71株が有効であることを示唆する。", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "162695", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "寺平, 拓也"}]}, {"nameIdentifiers": [{"nameIdentifier": "162696", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "原, 崇"}]}, {"nameIdentifiers": [{"nameIdentifier": "162697", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "熊谷, 武久"}]}, {"nameIdentifiers": [{"nameIdentifier": "162698", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "井口, 真理子"}]}, {"nameIdentifiers": [{"nameIdentifier": "162699", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "城, 斗志夫"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学農学部"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00183393", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03858634", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Teradaira, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "162690", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hara, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "162691", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kumagai, Takehisa"}], "nameIdentifiers": [{"nameIdentifier": "162692", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iguchi, Mariko"}], "nameIdentifiers": [{"nameIdentifier": "162693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Joh, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "162694", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "65(2)_149-155.pdf", "filesize": [{"value": "755.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 755100.0, "url": {"label": "65(2)_149-155.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/28305/files/65(2)_149-155.pdf"}, "version_id": "52d8b558-d5aa-4cf8-9826-903da9931ebe"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Lactobacillus paracasei K71", "subitem_subject_scheme": "Other"}, {"subitem_subject": "IgE", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Th1/Th2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CXCR3 (CD183)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CCR4 (CD194)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71"}, {"subitem_title": "Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1591"], "permalink_uri": "http://hdl.handle.net/10191/22578", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-05-29"}, "publish_date": "2013-05-29", "publish_status": "0", "recid": "28305", "relation": {}, "relation_version_is_last": true, "title": ["Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71"], "weko_shared_id": null}