{"_buckets": {"deposit": "411aee14-cdfa-4557-b8dd-39235d38c9fa"}, "_deposit": {"id": "28305", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "28305"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00028305"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Lactobacillus paracasei K71\u6295\u4e0e\u306b\u3088\u308b\u30aa\u30dc\u30a2\u30eb\u30d6\u30df\u30f3\u611f\u4f5c\u3057\u305fBALB/c\u30de\u30a6\u30b9\u306b\u304a\u3051\u308bTh1\u7d30\u80de\u5897\u52a0\u3068Th2\u7d30\u80de\u6e1b\u5c11"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "155", "bibliographicPageStart": "149", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a"}, {"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Lactobacillus paracasei K71 (L. paracasei K71) with stimulatory activity for interleukin-12 (IL-12) production has been isolated from Sakekasu (sake lees), a Japanese traditional fermented food coproduced during sake brewing. Oral administration of L. paracasei K71 significantly reduced serum immunoglobulin (Ig) E level in ovalbumin (OVA)-immunized BALB/c mice with type 2 helper T (Th2) polarization. In the present study, we examined the influence of L. paracasei K71 on Th1/Th2 cells population in spleen, employing OVA-immunized BALB/c mice. Orally administration of L. paracasei K71 resulted in an increase of CD4^+ T cells expressing CXCR3 (CD183) and a decrease of CD4^+ T cells expressing CCR4 (CD194) in splenocytes, in parallel with a reduction of total and OVA-specific IgE levels in serum. Since Th1 cells and Th2 cells preferentially express CXCR3 and CCR4 respectively, it seems that L. paracasei K71 can potentially induce Th1 cells and reduce Th2 cells in vivo, leading to down-regulation of IgE synthesis. The splenocytes from L. paracasei K71-administrated mice also showed lower IgE production level than those from control mice. These results suggest that L. paracasei K71 might be useful for improving Th2-dependent allergic diseases.", "subitem_description_type": "Abstract"}, {"subitem_description": "Lactobacillus paracasei K71 (K71\u682a) \u306f\u3001IL-12\u7523\u751f\u4fc3\u9032\u4f5c\u7528\u3092\u6709\u3059\u308b\u4e73\u9178\u83cc\u3068\u3057\u3066\u65e5\u672c\u9152\u306e\u9152\u7c95\u3088\u308a\u5206\u96e2\u3055\u308c\u305f\u3002Th2\u512a\u4f4d\u306e\u72b6\u614b\u306b\u3042\u308bBALB/c \u30de\u30a6\u30b9\u306b\u30aa\u30dc\u30a2\u30eb\u30d6\u30df\u30f3\u611f\u4f5c\u3057\u3001\u3053\u306e\u30de\u30a6\u30b9\u306bK71\u682a\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3068\u3001\u8840\u4e2dIgE \u30ec\u30d9\u30eb\u4ea2\u9032\u3092\u9855\u8457\u306b\u6291\u5236\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001OVA \u611f\u4f5c\u3057\u305fBALB/c \u30de\u30a6\u30b9\u3092\u7528\u3044\u3001\u813e\u81d3\u306b\u304a\u3051\u308bTh1/ Th2\u30d0\u30e9\u30f3\u30b9\u306b\u53ca\u307c\u3059K71\u682a\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002K71\u682a\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3068\u3001\u8840\u4e2d\u306e\u7dcfIgE \u304a\u3088\u3073OVA \u7279\u7570\u7684IgE \u30ec\u30d9\u30eb\u4ea2\u9032\u3092\u6291\u5236\u3059\u308b\u3068\u540c\u6642\u306b\u3001\u813e\u81d3\u306b\u304a\u3051\u308bCXCR3 (CD183) \u967d\u6027CD4^+T \u7d30\u80de\u306e\u5897\u52a0\u3068CCR4 (CD194) \u967d\u6027CD4^+T \u7d30\u80de\u306e\u6e1b\u5c11\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002K71\u682a\u6295\u4e0e\u7fa4\u30de\u30a6\u30b9\u813e\u81d3\u7d30\u80de\u306f\u3001\u5bfe\u8c61\u7fa4\u30de\u30a6\u30b9\u813e\u81d3\u7d30\u80de\u3088\u308aIgE \u7523\u751f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3002Th1\u304a\u3088\u3073Th2\u7d30\u80de\u306f\u305d\u308c\u305e\u308cCXCR3\u3068CCR4\u3092\u7279\u5fb4\u7684\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u304b\u3089\u3001K71\u682a\u306f\u751f\u4f53\u5185\u3067Th1\u7d30\u80de\u306e\u5897\u52a0\u3068Th2\u7d30\u80de\u306e\u6e1b\u5c11\u3092\u4fc3\u3057\u3001IgE \u7523\u751f\u306e\u6291\u5236\u306b\u7e4b\u304c\u308b\u3053\u3068\u304c\u4f3a\u3048\u308b\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u306f\u3001Th2\u578b\u514d\u75ab\u5fdc\u7b54\u304c\u95a2\u4e0e\u3059\u308b\u30a2\u30ec\u30eb\u30ae\u30fc\u75be\u60a3\u306e\u6539\u5584\u306bK71\u682a\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "162695", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "\u5bfa\u5e73, 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"Th1/Th2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CXCR3 (CD183)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CCR4 (CD194)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Induction of Th1 Cells and Reduction of Th2 Cells in Ovalbumin-immunized BALB/c Mice upon Oral Administration of Lactobacillus paracasei K71"}, {"subitem_title": "Induction of Th1 Cells and Reduction of Th2 Cells in 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