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Immunohistochemical study on the fetal rat pituitary in hyperthermia-induced exencephaly
http://hdl.handle.net/10191/6257
http://hdl.handle.net/10191/62574049c82c-341f-487d-abd2-9b3f5eb191d4
名前 / ファイル | ライセンス | アクション |
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08_0003.pdf (865.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunohistochemical study on the fetal rat pituitary in hyperthermia-induced exencephaly | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hyperthermia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exencephaly | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pituitary | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adrenal atrophy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fetal rat | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Watanabe, Yuichi G.
× Watanabe, Yuichi G. |
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著者別名 | ||||||
識別子 | 38374 | |||||
識別子Scheme | WEKO | |||||
姓名 | 渡辺, 勇一 | |||||
言語 | ja | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hyperthermia of fetal rats is known to cause malformations of various organs including brain. The present study was carried out to investigate the effect of the hyperthermia-induced brain damages on the development of the adenohypophysis. Mother rats of Day 9.5 of pregnancy were anesthetized and immersed in hot water (43℃) for 15 min. At Day 21.5 of gestation, fetuses were removed by caesarian section and examined for exencephaly. Hyperthermal stress induced varying degrees of exencephaly in 36% of surviving fetal rats. In extreme cases a considerable part of head was lost. Even in those fetuses with severe brain deformities, the hypophysial stalk and neural lobe were present though they were markedly underdeveloped. In exencephalic fetuses, no immunoreactive vasopressin was detected in the neural lobe of the hypophysis. Immunohistochemical examination of the adenohypophysis showed that exencephaly caused a marked decrease in the number of growth hormone (GH)-producing cells. Other types of hormone-producing cells appeared to be unaffected by brain anomaly. The reason for a decreased population of GH cells in exencephalic fetuses is discussed in relation to their adrenocortical hypotrophy. | |||||
言語 | en | |||||
書誌情報 |
en : Zoological Science 巻 19, 号 6, p. 689-694, 発行日 2002 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Zoological Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0289-0003 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10545874 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://doi.org/10.2108/zsj.19.689 | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
著者版フラグ | ||||||
値 | publisher |