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In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells
http://hdl.handle.net/10191/1182
http://hdl.handle.net/10191/1182ace35b0b-1430-4825-a1a6-c67197476d97
名前 / ファイル | ライセンス | アクション |
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24_0009.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-04-23 | |||||
タイトル | ||||||
タイトル | In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human umbilical vein endothelial cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endothelial cell damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyclosporin A | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitomycin C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Prednisolone. | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Seki, Yoshinobu
× Seki, Yoshinobu× Toba, Ken× Fuse, Ichiro× Sato, Naoki× Niwano, Hiroe× Takahashi, Hoyu× Tanabe, Naohito× Aizawa, Yoshifusa |
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著者別名 | ||||||
識別子 | 38271 | |||||
識別子Scheme | WEKO | |||||
姓名 | 鳥羽, 健 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Vascular endothelial cell damage plays an important role in microvascular thrombogenesis. In vivo administration of cyclosporin A or mitomycin C sometimes results in thrombotic microangiopathy in patients. Materials and methods: The effects of cyclosporin A, mitomycin C and/or prednisolone on the cell cycle in cultured human umbilical vein endothelial cells were investigated to evaluate drug-induced endothelial cell damage and the protective effect of prednisolone on endothelial cells against the damage by cyclosporin A or mitomycin C in vitro. Results: The addition of cyclosporin A to cultures caused proliferation arrest in the G1-phase in a dose-dependent manner, while mitomycin C inhibited DNA synthesis, which resulted in cell cycle arrest and inhibition of BrdUrd incorporation in the S-phase. The administration of prednisolone also caused cell cycle arrest in the G1 by itself, and protected the cells from the damage caused by mitomycin C. The inhibitory effects of cyclosporin A and prednisolone on the cell cycle were reversible, while mitomycin C was not. The highly phosphorylated retinoblastoma protein expressed in human umbilical vein endothelial cells decreased in the presence of mitomycin C. Soluble thrombomodulin levels in the culture supernatant were elevated by the addition of cyclosporin A. Conclusion: These effects of the drugs may cause the cell cycle arrest and the prolonged repair of damaged endothelial cells in patients. D 2004 Elsevier Ltd. All rights reserved. | |||||
書誌情報 |
Thrombosis Research en : Thrombosis Research 巻 115, 号 3, p. 219-228, 発行日 2005-03 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00493848 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00863148 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1016/j.thromres.2004.09.001 | |||||
権利 | ||||||
権利情報 | Elsevier Ltd | |||||
著者版フラグ | ||||||
値 | author |