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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 300 医歯学総合病院
  2. 10 学術雑誌論文
  3. 10 査読済論文

In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells

http://hdl.handle.net/10191/1182
ace35b0b-1430-4825-a1a6-c67197476d97
名前 / ファイル ライセンス アクション
24_0009.pdf 24_0009.pdf (1.1 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
タイトル In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells
タイトル
言語 en
タイトル In vitro effect of cyclosprine A, mitomycin C and prednisolone on cell kinetics in cultured human umbilical vein endothelial cells
言語
言語 eng
キーワード
主題Scheme Other
主題 Human umbilical vein endothelial cells
キーワード
主題Scheme Other
主題 Endothelial cell damage
キーワード
主題Scheme Other
主題 Cell cycle
キーワード
主題Scheme Other
主題 Cyclosporin A
キーワード
主題Scheme Other
主題 Mitomycin C
キーワード
主題Scheme Other
主題 Prednisolone.
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Seki, Yoshinobu

× Seki, Yoshinobu

WEKO 38263

Seki, Yoshinobu

Search repository
Toba, Ken

× Toba, Ken

WEKO 38264

Toba, Ken

Search repository
Fuse, Ichiro

× Fuse, Ichiro

WEKO 38265

Fuse, Ichiro

Search repository
Sato, Naoki

× Sato, Naoki

WEKO 38266

Sato, Naoki

Search repository
Niwano, Hiroe

× Niwano, Hiroe

WEKO 38267

Niwano, Hiroe

Search repository
Takahashi, Hoyu

× Takahashi, Hoyu

WEKO 38268

Takahashi, Hoyu

Search repository
Tanabe, Naohito

× Tanabe, Naohito

WEKO 38269

Tanabe, Naohito

Search repository
Aizawa, Yoshifusa

× Aizawa, Yoshifusa

WEKO 38270

Aizawa, Yoshifusa

Search repository
著者別名
識別子
識別子 38271
識別子Scheme WEKO
姓名
姓名 鳥羽, 健
抄録
内容記述タイプ Abstract
内容記述 Introduction: Vascular endothelial cell damage plays an important role in microvascular thrombogenesis. In vivo administration of cyclosporin A or mitomycin C sometimes results in thrombotic microangiopathy in patients. Materials and methods: The effects of cyclosporin A, mitomycin C and/or prednisolone on the cell cycle in cultured human umbilical vein endothelial cells were investigated to evaluate drug-induced endothelial cell damage and the protective effect of prednisolone on endothelial cells against the damage by cyclosporin A or mitomycin C in vitro. Results: The addition of cyclosporin A to cultures caused proliferation arrest in the G1-phase in a dose-dependent manner, while mitomycin C inhibited DNA synthesis, which resulted in cell cycle arrest and inhibition of BrdUrd incorporation in the S-phase. The administration of prednisolone also caused cell cycle arrest in the G1 by itself, and protected the cells from the damage caused by mitomycin C. The inhibitory effects of cyclosporin A and prednisolone on the cell cycle were reversible, while mitomycin C was not. The highly phosphorylated retinoblastoma protein expressed in human umbilical vein endothelial cells decreased in the presence of mitomycin C. Soluble thrombomodulin levels in the culture supernatant were elevated by the addition of cyclosporin A. Conclusion: These effects of the drugs may cause the cell cycle arrest and the prolonged repair of damaged endothelial cells in patients. D 2004 Elsevier Ltd. All rights reserved.
書誌情報 Thrombosis Research
en : Thrombosis Research

巻 115, 号 3, p. 219-228, 発行日 2005-03
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 00493848
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00863148
DOI
関連識別子
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.thromres.2004.09.001
権利
権利情報 Elsevier Ltd
著者版フラグ
値 author
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