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The Expression of Estrogen Receptor α (Er α) in the rat Temporomandibular Joint
http://hdl.handle.net/10191/1801
http://hdl.handle.net/10191/1801a1d74599-df7e-4764-852a-20ef7098884d
| 名前 / ファイル | ライセンス | アクション |
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9_0008.pdf (125.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | The Expression of Estrogen Receptor α (Er α) in the rat Temporomandibular Joint | |||||
| タイトル | ||||||
| タイトル | The Expression of Estrogen Receptor α (Er α) in the rat Temporomandibular Joint | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | estrogen receptor α | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | temporomandibular joint | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | synovial membrane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunocytochemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | in situ hybridization | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamada, Kazuho
× Yamada, Kazuho× Nozawa-Inoue, Kayoko× Kawano, Yoshiro× Kohno, Shoji× Amizuka, Norio× Iwanaga, Toshihiko× Maeda, Takeyasu |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 38130 | |||||
| 姓名 | 野澤-井上, 佳世子 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Numerous epidemiological studies have pointed out a higher frequency of temporomandibular disorder (TMD) in women than in men, suggesting the involvement of a sex hormone such as estrogen in the pathogenesis of TMD. Although estrogen is known to play pivotal roles in osteoarthrosis or rheumatoid arthritis in systemic joints, there have been few reports about the role of estrogen in the temporomandibular joint (TMJ). Its effect is generally mediated by estrogen receptors (ERs), ERα and ERβ, the former which is a predominant type. In this study, we examined the expression of ERα protein and mRNA in the TMJ of adult male rats by immunocytochemistry and in situ hybridization histochemistry. Intense ERα-immunoreactivity was localized in the synovial lining cells, stromal cells in the articular disc, and chondrocytes in the TMJ. These ERα-immunopositive synovial lining cells were characteristic of cytoplasmic processes identified with confocal and immuno-electron microscopy, suggesting that they were synovial type B cells. In situ hybridization histochemistry confirmed intense signals for ERα in the synovial lining cells and the sublining fibroblasts at mRNA levels. The nuclei of chondrocytes showed an intense immunoreaction for ERα in the area of the maturative and hypertrophic layer of the articular cartilage. In addition to the nuclear localization of ERα, a weak immunoreaction appeared in the cytoplasm of some ERα-positive cells. These findings supported the hypothesis that the TMJ tissue --at least in the male rat-- has the potential to be an estrogen target tissue. | |||||
| 書誌情報 |
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology en : The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology 巻 274A, 号 2, p. 934-941, 発行日 2003-10 |
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| 出版者 | ||||||
| 出版者 | John Wiley & Sons Ltd. | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15524884 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11814687 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1002/ar.a.10107 | |||||
| 権利 | ||||||
| 権利情報 | Wiley-Liss, Inc. | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
