{"_buckets": {"deposit": "740bbf73-036c-4922-9e67-94d6c7f3f121"}, "_deposit": {"id": "25958", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25958"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00025958"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1995-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "7", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "25", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Electrophysiological and mechanical effects of nicotine in the right and left atrial muscles of rat were investigated. Nicotine (300\u03bcM and 1mM) decreased the action potential amplitude (APA). The resting potential (RP) was depolarized. The action potential duration (APD, at 90% repolarization) of the right atrium was prolonged, whereas the APD of the left atrium was shortened. The responses were concentration-dependent. In the right atrium, nicotine prolonged the cycle length. Nicotine (10\u03bcg to 1mg) caused a negative inotropic effect in both the right and left atria in a concentration-dependent manner. The responses were potentiated with an increase in the frequencies of stimulation (0.5 to 3Hz). Nicotine caused more potent depressant effects on the right atrium than on the left atrium. The effects were not modified by atropine (1\u03bcM) and hexamethonium (lmM). Addition of isoproterenol (2\u03bcM) recovered the depressed action potentials induced by nicotine (300\u03bcM). The responses were reversible. These results indicate that nicotine causes only the negative responses on rat atria due to its direct action, and suggest that the differences between the electrophysiological and mechanical effects of nicotine on the right and left atria would result from physiological and anatomical properties of rat atria.", "subitem_description_type": "Abstract"}, {"subitem_description": 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"subitem_subject_scheme": "Other"}, {"subitem_subject": "Chronotropic effect", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inotropic effect", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rat atrial muscles", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Nicotine actions on the action potentials and the contractile force in the rat atrial muscles : Comparison between the right and left atria", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Nicotine actions on the action potentials and the contractile force in the rat atrial muscles : Comparison between the right and left atria"}, {"subitem_title": "Nicotine actions on the action potentials and the contractile force in the rat atrial muscles : Comparison between the right and left atria", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "432/1291/1292/1328"], "permalink_uri": "http://hdl.handle.net/10191/22922", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2013-08-20"}, "publish_date": "2013-08-20", "publish_status": "0", "recid": "25958", "relation": {}, "relation_version_is_last": true, "title": ["Nicotine actions on the action potentials and the contractile force in the rat atrial muscles : Comparison between the right and left atria"], "weko_shared_id": null}