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To evaluate the maternal factors which contribute to cleft lip and/or palate, we performed a case-control study using a questionnaire specially designed for this study. One hundred and seven mothers of patients born from 1990 to 1995 and referred to our clinic were divided into two groups, 75 with children with a cleft lip or cleft lip and palate (cleft lip group) and 32 with children with a cleft palate only (cleft palate group). The control group consisted of 201 mothers with healthy babies born in 1993. Various factors were compared statistically among these three groups. Statistical significance was observed between the cleft lip group and control group for one factor-the incidence of a common cold at the beginning of pregnancy. 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