{"_buckets": {"deposit": "486e6050-cf0d-484d-90e9-ac643533bbb6"}, "_deposit": {"id": "25570", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25570"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00025570"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Molecular mechanisms of abnormal chondrocyte differentiation in the fetal cranial base caused by the effect of activated FGFR2 signaling"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "48", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Apert syndrome exhibits the specific clinical features including abnormal premature fusion of calvarial sutures and syndactyly, which are known to be caused by miss sense mutations of Ser252Trp or Pro253Arg on Fibroblast growth factor receptor 2(FGFR2) gene responsible for abnormal activation of the tyrosin kinase and osteoblast differentiation. On the other hand, premature bony fusion of cranial base synchondroses are another major skeletal abnormalities, however the mutant FGFR2 signaling in the cranial cartilage is still remain to be elucidated. Purpose of this study is to clarify molecular mechanism of the craniofacial endochondral growth affected by abnormal FGFR2 signaling. Transgenic mice bearing the Apert type mutant Fgfr2 gene (Fgfr2\u2162CP253R) driven by promoter/enhancer of Col2a1 gene were used to analyze the effect of cartilage specific expression. Elevated expression level of Runx2/Cbfa1, Indian hedgehog (Ihh) and Matrix metalloproteinase13 (Mmp-13) suggested accelerated chondrocytes differentiation with the exogenous Fgfr2\u2162CP253R gene expression in cranial base cartilage. Taken together with histological findings showing reduced size of cranial base cartilage and accelerated bone formations, activated FGFR2 signaling negatively regulate the growth of cranial base through modulating the endochondral growth process.", "subitem_description_type": "Abstract"}, {"subitem_description": "Apert\u75c7\u5019\u7fa4\u306f\u982d\u84cb\u51a0\u7e2b\u5408\u65e9\u671f\u7570\u5e38\u7652\u5408\u3084\u5408\u6307\u75c7\u306a\u3069\u7279\u5fb4\u7684\u306a\u75c5\u614b\u3092\u5448\u3057\u3001Fibroblast growth factor receptor 2(FGFR2)\u907a\u4f1d\u5b50\u306e\u30bb\u30ea\u30f3252\u30c8\u30ea\u30d7\u30c8\u30d5\u30a1\u30f3\u3042\u308b\u3044\u306f\u30d7\u30ed\u30ea\u30f3253\u30a2\u30eb\u30ae\u30cb\u30f3\u306a\u3069\u306e\u30ec\u30bb\u30d7\u30bf\u30fc\u6d3b\u6027\u5316\u578b\u30df\u30b9\u30bb\u30f3\u30b9\u304c\u982d\u84cb\u51a0\u7e2b\u5408\u90e8\u306e\u9aa8\u82bd\u7d30\u80de\u306e\u5206\u5316\u3092\u4ea2\u9032\u3059\u308b\u3053\u3068\u304c\u539f\u56e0\u3068\u3055\u308c\u3066\u3044\u308b\u3002\u4e00\u65b9\u3067Apert\u75c7\u5019\u7fa4\u306b\u304a\u3044\u3066\u8edf\u9aa8\u7e2b\u5408\u306e\u65e9\u671f\u7570\u5e38\u9589\u9396\u304c\u3082\u3046\u4e00\u3064\u306e\u4e3b\u8981\u306a\u9aa8\u683c\u7570\u5e38\u3067\u3042\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u8edf\u9aa8\u5185\u306b\u304a\u3051\u308b\u5909\u7570\u578bFGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u5f79\u5272\u306f\u5b9a\u7fa9\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001FGFR2\u306e\u6d3b\u6027\u5316\u304c\u982d\u84cb\u9854\u9762\u306e\u8edf\u9aa8\u6027\u6210\u9577\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u5206\u5b50\u6a5f\u69cb\u306e\u4e00\u7aef\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002\u5b9f\u9a13\u52d5\u7269\u306b\u306fApert\u75c7\u5019\u7fa4\u578b\u5909\u7570Fgfr2\u907a\u4f1d\u5b50(Fgfr2\u2162cP253R)\u30922\u578b\u30b3\u30e9\u30b2\u30f3\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u3088\u3063\u3066\u8edf\u9aa8\u7d44\u7e54\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9(Tg\u30de\u30a6\u30b9)\u3092\u7528\u3044\u305f\u3002\u5909\u7570Fgfr2\u2162CP253R\u907a\u4f1d\u5b50\u5c0e\u5165\u306b\u4f34\u3044Runx2/Cbfa1,Indian hedgehog(Ihh),Matrix metalloproteinase 13(Mpm-13)\u907a\u4f1d\u5b50\u306e\u691c\u51fa\u30ec\u30d9\u30eb\u4e0a\u6607\u304c\u8edf\u9aa8\u7d44\u7e54\u306b\u89b3\u5bdf\u3055\u308c\u3001FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6d3b\u6027\u5316\u304c\u8edf\u9aa8\u5206\u5316\u306b\u5909\u5316\u3092\u3082\u305f\u3089\u3057\u305f\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u7d44\u7e54\u6240\u898b\u306b\u304a\u3051\u308b\u982d\u84cb\u5e95\u8edf\u9aa8\u7e2b\u5408\u306e\u7e2e\u5c0f\u3068\u9aa8\u5316\u4ea2\u9032\u3092\u8003\u3048\u5408\u308f\u305b\u308b\u3068\u3001FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u304c\u8edf\u9aa8\u6027\u6210\u9577\u306e\u6291\u5236\u3092\u901a\u3058\u3066\u982d\u84cb\u5e95\u306e\u6210\u9577\u3092\u6291\u5236\u7684\u306b\u8abf\u7bc0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u7dcf\u3058\u3066\u3001FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306f\u9aa8\u82bd\u7d30\u80de\u7cfb\u3068\u8edf\u9aa8\u7d30\u80de\u7cfb\u306e\u7d30\u80de\u5206\u5316\u306b\u5bfe\u3059\u308b\u7d71\u5408\u7684\u306a\u8abf\u7bc0\u4f5c\u7528\u3092\u901a\u3058\u3066\u982d\u84cb\u9854\u9762\u306e\u5f62\u614b\u5f62\u6210\u3068\u767a\u80b2\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "150703", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Seki, Yukie"}]}, {"nameIdentifiers": [{"nameIdentifier": "150704", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nagata, Masaki"}]}, {"nameIdentifiers": [{"nameIdentifier": "150705", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kodama, Naoki"}]}, {"nameIdentifiers": [{"nameIdentifier": "150706", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takagi, Ritsuo"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u6b6f\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN0018300X", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03850153", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u95a2, \u96ea\u7d75"}], "nameIdentifiers": [{"nameIdentifier": "150699", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u6c38\u7530, \u660c\u6bc5"}], "nameIdentifiers": [{"nameIdentifier": "150700", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u5c0f\u7389, \u76f4\u6a39"}], "nameIdentifiers": [{"nameIdentifier": "150701", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u9ad8\u6728, \u5f8b\u7537"}], "nameIdentifiers": [{"nameIdentifier": "150702", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "NS_36(1)_39-48.pdf", "filesize": [{"value": "5.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 5100000.0, "url": {"label": "NS_36(1)_39-48.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/25570/files/NS_36(1)_39-48.pdf"}, "version_id": "b20dc5d7-0eef-48fc-a4f7-eb1984a41c67"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "fibroblast growth factor receptor type 2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "FGFR2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Apert syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u982d\u84cb\u5e95", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8edf\u9aa8\u5206\u5316", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8edf\u9aa8\u7e2b\u5408", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6d3b\u6027\u5316\u304c\u80ce\u4ed4\u982d\u84cb\u5e95\u306e\u8edf\u9aa8\u5206\u5316\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u3068\u5206\u5b50\u6a5f\u69cb\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6d3b\u6027\u5316\u304c\u80ce\u4ed4\u982d\u84cb\u5e95\u306e\u8edf\u9aa8\u5206\u5316\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u3068\u5206\u5b50\u6a5f\u69cb\u306e\u691c\u8a0e"}, {"subitem_title": "FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6d3b\u6027\u5316\u304c\u80ce\u4ed4\u982d\u84cb\u5e95\u306e\u8edf\u9aa8\u5206\u5316\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u3068\u5206\u5b50\u6a5f\u69cb\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "432/1291/1292/1306"], "permalink_uri": "http://hdl.handle.net/10191/23088", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2013-08-23"}, "publish_date": "2013-08-23", "publish_status": "0", "recid": "25570", "relation": {}, "relation_version_is_last": true, "title": ["FGFR2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u6d3b\u6027\u5316\u304c\u80ce\u4ed4\u982d\u84cb\u5e95\u306e\u8edf\u9aa8\u5206\u5316\u306b\u304a\u3088\u307c\u3059\u5f71\u97ff\u3068\u5206\u5b50\u6a5f\u69cb\u306e\u691c\u8a0e"], "weko_shared_id": null}