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  1. 060 工学部
  2. 20 紀要
  3. 99 その他
  1. 0 資料タイプ別
  2. 03 紀要論文

ヒト唾液ペプチドの抗菌機能を活用したヘルスケア製品の開発

http://hdl.handle.net/10191/26367
http://hdl.handle.net/10191/26367
1fd339b9-de7d-4059-9375-893dc708c0e9
名前 / ファイル ライセンス アクション
15_9-14.pdf 15_9-14.pdf (4.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-17
タイトル
タイトル ヒト唾液ペプチドの抗菌機能を活用したヘルスケア製品の開発
タイトル
言語 en
タイトル ヒト唾液ペプチドの抗菌機能を活用したヘルスケア製品の開発
言語
言語 jpn
キーワード
主題Scheme Other
主題 human saliva
キーワード
主題Scheme Other
主題 histatin 3
キーワード
主題Scheme Other
主題 short proteolytic peptides
キーワード
主題Scheme Other
主題 Porphyromonas gingivalis
キーワード
主題Scheme Other
主題 antimicrobial peptide
キーワード
主題Scheme Other
主題 membrane depolarization
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル A Study on Application of Human Salivary Peptides with Antimicrobial Activities to Healthcare Products
著者 大滝, 俊樹

× 大滝, 俊樹

WEKO 149566

大滝, 俊樹

Search repository
高橋, 信輝

× 高橋, 信輝

WEKO 149567

高橋, 信輝

Search repository
武井, 教展

× 武井, 教展

WEKO 149568

武井, 教展

Search repository
谷口, 正之

× 谷口, 正之

WEKO 149569

谷口, 正之

Search repository
斎藤, 英一

× 斎藤, 英一

WEKO 149570

斎藤, 英一

Search repository
著者別名
識別子 149571
識別子Scheme WEKO
姓名 Ohtaki, Toshiki
著者別名
識別子 149572
識別子Scheme WEKO
姓名 Takahashi, Nobuteru
著者別名
識別子 149573
識別子Scheme WEKO
姓名 Takei, Norinobu
著者別名
識別子 149574
識別子Scheme WEKO
姓名 Taniguchi, Masayuki
著者別名
識別子 149575
識別子Scheme WEKO
姓名 Saitoh, Eiichi
抄録
内容記述タイプ Abstract
内容記述 Human salivary histidine-rich polypeptides, histatin 1 (38 ammo acids) and histatin 3 (32 aa) are major antimicrobial peptides harboring potent fungicidal activity against Candida albicans. This study was undertaken to examine the activity of four short peptide fragments, histatins 5 (24 aa), 8 (12 aa), 9 (14 aa), and 11 (8 aa), derived from histatin 3 against Porphyromonas gingivalis (penodontal bacteria). By determining the concentration of ATP synthesized by microorganism, histatins 5, 8, 9, and 11 were found to inhibit the growth of P. gingivalis with 50 % inhibitory concentrations (IC_50s) of 33.4, >800, 9.7, and 294.1 μM, respectively. Cytoplasmic membrane depolarization of P. gingivalis by the peptides was elucidated using the membrane-potential-sensitive dye, diSC_3-5. All of the fragments of histatin 3 caused membrane depolarization of 10.4 - 43.9 % at 33.4μM in a good's buffer (5 mM HEPES, pH 7.2, 50 mM glucose) and of 3.5 - 25 % in physiological condition (4 mM NaH_2PO_4/Na_2HP0_4, pH 7.0, 30mM NaCl), respectively. Taken together, it can be concluded that even shorter peptide fragments derived from human histatin 3, show potent antibactencidal activity against P. gingivalis. Thereby, antimicrobial peptides reported here appear to be excellent candidates for oral healthcare products.
書誌情報 新潟工科大学研究紀要
en : 新潟工科大学研究紀要

巻 15, p. 9-14, 発行日 2010-12
出版者
出版者 新潟工科大学
ISSN
収録物識別子タイプ ISSN
収録物識別子 1342792X
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN10590360
著者版フラグ
値 publisher
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