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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第100巻第10号

血小板アラキドン酸代謝の高速液体クロマトグラフィー(HPLC)による解析

http://hdl.handle.net/10191/35502
http://hdl.handle.net/10191/35502
ad427879-699b-40b6-8ee3-4708cd18c290
名前 / ファイル ライセンス アクション
100(10)_614-621.pdf 100(10)_614-621.pdf (638.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-12-11
タイトル
タイトル 血小板アラキドン酸代謝の高速液体クロマトグラフィー(HPLC)による解析
タイトル
言語 en
タイトル 血小板アラキドン酸代謝の高速液体クロマトグラフィー(HPLC)による解析
言語
言語 jpn
キーワード
主題Scheme Other
主題 platelet
キーワード
主題Scheme Other
主題 arachidonate metabolism
キーワード
主題Scheme Other
主題 HPLC
キーワード
主題Scheme Other
主題 platelet function abnormality
キーワード
主題Scheme Other
主題 血小板アラキドン酸代謝
キーワード
主題Scheme Other
主題 HPLC
キーワード
主題Scheme Other
主題 血小板機能異常症
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Analysis of human platelet arachidonate metabolism by high performance liquid chromatography (HPLC)
著者 布施, 一郎

× 布施, 一郎

WEKO 146559

布施, 一郎

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著者別名
識別子 146560
識別子Scheme WEKO
姓名 Fuse, Ichiro
抄録
内容記述タイプ Abstract
内容記述 In order to evaluate whether the arachidonic acid metabolism of the platelets from patients with platelet dysfunction is nomal or not, the analysis of the metabolites via cyclo-oxygenase and lipoxygenase pathway was done, using high performance liquid chromatography(HPLC). Reversed phase HPLC for analysis of the lipoxygenase products revealed 5-HETE, 12-HETE and 15-HETE in the supernatants from normal washed human platelets induced by arachidonic acid(0.2mM). PGD_2, TXB_2 and PGE_2, which are the cyclo-oxygenase products, were also identified in the supernatants using 9-anthryl-diazomethane derivatization of prostaglandins for normal phase HPLC. Although 5-HETE and 15-HETE were produced by the contaminated polymorphonuclear leukocytes, the metabolites of arachidonic acid could be separated well and be detected at high sensitivity. According to these facts, the assay method using HPLC could be a useful tool for not only the detection of a series of arachidonic acid metabolites in human platelets, but also the diagnosis of the patients who show platelet function abnormality.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 100, 号 10, p. 614-621, 発行日 1986-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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