{"_buckets": {"deposit": "8da732c0-0c54-4217-9b8a-24607f650191"}, "_deposit": {"id": "23498", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "23498"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00023498", "sets": ["456", "1222"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Experimental and Clinical Study on Systemic Intoxication and Local Lesions Produced by Habu-Snake Bite : with special reference to how to overcome serious systemic and topical pathologies in cases in which antivenin therapy can not be used or its usage is delayed to be effective"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1988-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "301", "bibliographicPageStart": "283", "bibliographicVolumeNumber": "102", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The aim of this study is to analyze systemic and topical pathologies caused by Habu-snake bite experimentally and clinically, and to search for effective methods to overcome these pathologies in case in which antivenin therapy is not feasible because of positive skin test or its administration is too delayed to be effective. Materials and Method: Systemic pathologies were investigated with 9 mongrel dogs in which Habu-snake venom was administered 10-20mg/kg into the femoral muscle or 1.0mg/kg into the central vein under penthobarbital anesthesia. E. C. G. , arterial pressure, central venous pressure (C.V.P.), arterial blood gas, electrolytes, lactic acid, serum hemoglobin etc. were analysed periodically through out the period starting before the injection till the ultimate death of a dog. Records of 21 severely intoxicated cases by Habu-venom were studied as to the parameters investigated experimentally, 0.5-2.0mg/kg Habu-snake venom was injected into the intrinsic muscles of forefoot of 14 dogs and a Japanese monkey, and spreading of muscle necrosis and sequelae ensured were observed periodically, and the findings were compared with topical pathologies in 4 fresh cases and other 9 cases with severe sequelae left alone. Results: Experimental data indicated that cardiac suppression, metabolic (lactic) acidosis and dehydration caused by Habu-venom were lethal factors. Hemolysis, hyperkalemia coagulation disturbance and alarm reactions such as hemoconcentration, hyperglycemia were also observed, whereas in 21 fresh cases, systemic intoxication such as decreased blood pressure and/or acute renal failure were observed only in a few cases since grade of systemic intoxication is much lighter due to lesser amount of venom introduced and administration of antivenin, but alarm reaction was observed in most cases. Dissection of dog forelimbs revealed that the intrinsic muscles at the injected site underwent coagulation necrosis, but did not result in the typical intrinsic plus contracture, while only superficial forearm flexors were found partially necrotic suggesting that the venom spread through carpal tunnel into flexor side of forearm. In clinical cases with the bite at the forearm and leg, no severe contracture developed if fasciotomy was performed adequately, but in cases with the bite within the hand proper, often intrinsic plus contracture and/or low median nerve palsy ensued. Conclusion: Systemic therapy in Habu-snake bite when antivenin therapy can not be given or delayed to be effective should be directed to normalization of metabolic acidosis, supplement of intravenous fluid based on the analysis of arterial blood gas and C. V. P monitoring. Fasciotomy is indicated when leg or forearm and absolutely when hand proper is bitten in order to prevent muscle necrosis and contracture ensued.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "141418", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Inoue, Osamu"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "井上, 治"}], "nameIdentifiers": [{"nameIdentifier": "141417", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "102(5)_283-301.pdf", "filesize": [{"value": "9.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 9000000.0, "url": {"label": "102(5)_283-301.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/23498/files/102(5)_283-301.pdf"}, "version_id": "149ca429-06b2-4bd1-aeca-61f6b5a79dce"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Habu-snake bite", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Systemic intoxication", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Local lesion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ハブ咬傷", "subitem_subject_scheme": "Other"}, {"subitem_subject": "全身性中毒作用", "subitem_subject_scheme": "Other"}, {"subitem_subject": "局所病変", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ハブ咬傷における全身性中毒作用および咬傷部の局所的病変についての実験的および臨床的研究 : とくに抗毒素投与の禁忌例および遅延例における全身的および局所的対症療法の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ハブ咬傷における全身性中毒作用および咬傷部の局所的病変についての実験的および臨床的研究 : とくに抗毒素投与の禁忌例および遅延例における全身的および局所的対症療法の検討"}, {"subitem_title": "ハブ咬傷における全身性中毒作用および咬傷部の局所的病変についての実験的および臨床的研究 : とくに抗毒素投与の禁忌例および遅延例における全身的および局所的対症療法の検討", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1222"], "permalink_uri": "http://hdl.handle.net/10191/40762", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-04-05"}, "publish_date": "2016-04-05", "publish_status": "0", "recid": "23498", "relation": {}, "relation_version_is_last": true, "title": ["ハブ咬傷における全身性中毒作用および咬傷部の局所的病変についての実験的および臨床的研究 : とくに抗毒素投与の禁忌例および遅延例における全身的および局所的対症療法の検討"], "weko_shared_id": null}